Health Cures

CURES for Hepatitis

### Cures for HEPATITIS:

## Dr. KLENNER :

To read the “Clinical Guide to the Use of Vitamin C” by DoctorKLENNER, click here (html 148ko, equivalent 43pages in A4 Word): m_nutritherapy_klenner2.html

Dr. Klenner – (Intravenous) Vitamin C Paper -1971.

from : http://www.doctoryourself.com/klennerpaper.html

Viral hepatitis needs brief mentioning. There are two types:
1) Infectious hepatitis;
2) Needle hepatitis.

Physical activity has always been considered to increase the severity andprolong the course of the disease. [58] In Vietnam, Freebern andRepsher showed that pick-and-shovel details had no effects onthe 199 controls as against 199 kept at bed rest. [59] One thing iscertain. Given massive intravenous ascorbic acid therapy and patientsare well and back to work in from 3 to 7 days. In these cases thevitamin is also employed by mouth as follow-up therapy. Dr. Bauer atthe University Clinic, Basel, Switzerland, reported that just 10grams daily, intravenously, proved the best treatment available.

## A possible cure for Hepatitis? http://www.keelynet.com/biology/hepatits.htm

Posted on the KeelyNet BBS on May 15, 1992 as HEPATITS.ASC

This article was from Health Counselor magazine July/August 1991 issue.This is an excellent magazine for information on nature health careand nutrition. You can usually find it, at your local health foodstore. They usually give it away for free. Or ask your health food storeto carry it. I consider this a MUST HAVE to keep up with thelatest in natural health care. If you are unable to find it, you cancontact them at, Sante Publishing, P.O. Box 1914, Green Bay, Wisconsin54305. Ronald Barker

DISCOVERING A NATURAL CURE FOR HEPATITIS

`After contracting hepatitis B during surgery, here’s how onephysician fought back and cured himself.’
By Karolyn A. Gazella

Carson B. Burgstiner, M.D., was at the height of his career. He haddeveloped a thriving practice as an obstetrician/gynecologist inSavannah, Georgia. A highly trained and skilled microsurgeon, Dr.Burgstiner was devoted to his profession. But his profession nearly costhim his life.

THE ORDEAL BEGINS

“In 1983, I contracted hepatitis B after I had stuck my finger whileoperating on an infected patient,” recalled Dr. Burgstiner, who was49 at the time.

The discovery of the disease and the disasters that followed nearlydevastated Dr. Burgstiner and his wife, Jacque.

After his diagnosis, Dr. Burgstiner notified the Centers for DiseaseControl (CDC) and the Georgia State Board of Medical Examiners. Theyprovided guidelines for him to follow. Because he intended to cooperatefully, Dr. Burgstiner volunteered to have his patients undergoepidemiologic studies.

His patients stood behind him through his ordeal, Dr. Burgstinerexplained. “I was very fortunate to have such loyal patients,” he said.

Unfortunately, the local media soon learned that Dr. Burgstiner’s patientswere being tested for hepatitis. Headlines on the front page of themorning newspaper declared: “Source of Local Hepatitis OutbreakDiscovered!”

A detailed account of Dr. Burgstiner’s diagnosis was included in thearticle. Immediately, his successful practice and sterling reputation werejeopardized.

“The CDC and the local health department proved that none of the 26reported cases of hepatitis in the county were patients of mine.”

Dr. Burgstiner said. The newspaper subsequently published a retraction onits back page. The publicity added even more stress for the Burgstiners.

“After 26 years of medical practice without a lawsuit, suddenly I had twopast patients who claimed that exposure by surgery had caused theirhepatitis B,” said Dr. Burgstiner. As it turned out, both patients wereinfected by other sources.

Dr. Burgstiner was forced to discontinue obstetrics and major surgery,limiting his practice to minor surgery and office gynercology. He was anaggressive, motivated physician, and it was a painful transition. “Theeconomic and emotional impact was truly devastating,” he said.

DOCTOR BECOMES PATIENT

Coping with the shock of local publicity as well as the frustration ofhaving to refer all of his patients to colleagues for obstetrics and majorsurgery was just the beginning of Dr. Burgstiner’s struggle. The devastatingside effects and fear of dying from this disease began to surface.”A chronic hepatitis B carrier in the United States today has a 255percent chance of dying of liver cancer,” he said. “There is clearlyan epidemic of hepatitis B, with over 300,000 new cases beingdiagnosed yearly.”

The fear also haunted Dr. Burgstiner’s wife. “I remember when my husbandand I attended a conference where one of the speakers was discussinghepatitis B,” Mrs. Burgstiner recalled. This was when she realized theseverity of her husband’s condition.

Their fear and concern fueled their determination to fight the disease.The devoted doctor soon became and equally devoted patient. “I’ve alwaysbelieved strongly in the teachings of my professor of pathology, W.A.D.Anderson, M.D., who taught me that if you maintain normalphysiology, you prevent disease,” Dr. Burgstiner explained.

Dr. Burgstiner is the first to admit that he is somewhat unique in themedical establishment. “For the past 29 years I have believed in preventativemedicine, nutrition, exercise, and hormonal replacement,” he said. “Ifa gland dries up, you need to replace it.”

This philosophy virtually saved his practice and his life. Other than thehepatitis B, Dr. Burgstiner was in excellent health. He asked himself, whatgland could be deficient? What gland could he support in order tocombat his hepatitis: Armed with a thorough understanding of the humanbody, he realized the thymus gland was the key.

THE CRUCIAL THYMUS GLAND

“I had always been taught that the thymus gland (which is locatedwithin the upper chest) is large in infants but atrophies as we age,””he said. “The thymus gland has always been credited with controllingthe immune system.”

Because hepatitis B is an immune disease, Dr. Burgstiner sought anutritional supplement containing thymus tissue extract. He visitedhis local health food store, Brighter Day in Savannah.

Dr. Burgstiner began taking a thymus tissue extract supplement, alongwith 25,000 units be beta carotene and a multiple vitamin. Withinthree weeks, after a seven-year battle with an “incurable”disease, the E-antigen became weakly positive and the liver studiesturned up normal.

“After being tested every week for seven years, I almost didn’t believethe test results,” Dr. Burgstiner said. “Before I shared the news withJacque, I waited until a few more tests came back.” “I was so happy. Myprayers had been answered,” Mrs. Burgstiner said.

After another three weeks of following his own protocol, Dr. Burgstiner becameE-antigen negative and antibody positive. He was cured of hepatitis.To confirm his finding, he notified the CDC and had blood drawn at CandlerHospital, which was sent to Mass General (Harvard) and Scripps Institutein California. These prominent health facilities conducted many tests onhis blood, and all of them showed there was absolutely no trace of thevirus in his system.

Dr. Burgstiner shared his good news with a colleague he’d beencommunicating with about hepatitis research. Dr. Milton G. Mutchnick,a gastroenterologist/hepatologist at Wayne State University inDetroit, Michigan, had published controlled studies where he converted75 percent of his patients who were hepatitis B carries. “Iwas planning on getting into his next treatment group,” Dr. Burgstinerexplained. “When I called him and told him that I converted myself, heasked what I took.”

When Dr. Burgstiner told him he was taking an oral thymus extract,Dr. Mutchnick explained that he was using thymus injections in hisstudies. After their conversation, Dr. Burgstiner sent Dr. Mutchnicka bottle of the oral thymus supplement. Dr. Mutchnick’s preliminary testswith the product have given him the same startling results.

Today, Dr. Burgstiner is excited about the potential for helping others.”The impact of thymic hormonal replacement has enormous potential inimmune system diseases, from allergies and hay fever to rheumatoidarthritis, lupus, cancer, and AIDS,” he said. “This simple glandularhormone could answer a lot of prayers.”

Understandably, Mrs. Burgstiner is thrilled. Her husband has regained histhriving practice, but even more importantly, he has regained his health.”I’ve gotten a second chance, and I want to help as many people as I can,”Dr. Burgstiner said.

DEALING WITH HEPATITIS

Hepatitis is an infection of the liver caused by the hepatitis virus.Basically, there are two main strains of the hepatitis virus:

Hepatitis A is more common and more contagious. The chances ofcomplete recovery from hepatitis A are very good.

Hepatitis B, on the other hand, is much more serious. Withhepatitis B, the symptoms are more severe and last longer thanwith hepatitis A. One of the more serious outcomes of hepatitis B is chronicliver disease.

TRANSMISSION: Transmission of hepatitis B is very similar totransmission of the AIDS virus. Common sources of infection includeblood transfusions, intravenous drug abuse, needle punctures fromacupuncture or tattooing, and sexual contact.

The virus can spread through contact with infected saliva, nasal mucus,sperm and blood. Hepatitis B may also be transmitted through pregnancyfrom the infected mother to her unborn baby.

SYMPTOMS: The symptoms of any type of hepatitis include fatigue orextreme weakness, jaundice (yellowing of the skin and the whites of theeyes), nausea, dark brownish urine, fever, and abdominal discomfort. Theseverity and range of symptoms vary from case to case.

DIAGNOSIS: Hepatitis is suspected when the above-mentioned symptomsare present. Exact diagnosis is confirmed by specific blood tests thatdetermine elevated liver enzymes and measure antibody activity.

TREATMENT: Although there is presently no known cure forhepatitis B, a vaccination is available. Health care workers areespecially encouraged to get the vaccination.

Various nutritional factors should be considered in the treatment ofhepatitis B. Many natural liver-supporting techniques arealso recommended. The use of an oral thymic fraction supplement toconvert hepatitis B carries is presently being explored in moredetail.

Because hepatitis A is so contagious, scrupulous sanitation isessential. Clothing and bed linen require special handling when they arevisibly soiled, and should be laundered with a detergent that killsgerms. Contaminated toilets and floors should be cleaned with adisinfectant.

Patients with hepatitis A are advised to get plenty of bed rest. In thefirst few weeks of the infection, alcohol is prohibited. After a bout withhepatitis A, patients develop an immunity to the disease.

INCIDENCE OF SYMPTOMS IN HEPATITIS, ALL KINDS

SYMPTOM ………………… % OF PATIENTS

Dark Urine …………………… 94
Fatigue ……………………… 91
Loss Of Appetite ……………… 90
Nausea ………………………. 87
Fever ……………………….. 76
Vomiting …………………….. 71
Headache …………………….. 70
Abdominal Discomfort ………….. 65
Light Stools …………………. 52
Muscle Pain ………………….. 52
Drowsiness …………………… 49
Irritability …………………. 43
Itching ……………………… 42
Diarrhea …………………….. 25
Joint Pain …………………… 21

(Source: Encyclopedia of Natural Medicine, Michael Murray, N.D. and JosephPizzorno, N.D.)

AUTHOR’S NOTE:

Dr. Burgstiner remains very active within his community and hisprofession. He is past president of the Medical Association of Georgia andpresently serves as vice-chairman of the AMA’s Georgia Delegation. He isalso a Fellow of the American College of Surgeons and of the AmericanCollege of Preventative Medicine. We would like to thank the Burgstinersfor sharing their inspirational story.

Health Counselor has welcomed Dr. Brugstiner to our staff ofcontributing authors.

## Dr. Burgstiner’s Complete Thymic Formula and Vitamin/MineralComplex: http://www.thymic.com/index.php

This remarkable product combines comprehensive nutrition with herbaland glandular factors to form a solid and wholesome foundation ofnutritional support. Formulated by a nutritional pioneer, this allnatural formula is perfectly balanced with nutrients that are knownto bolster your body’s natural defense system.

THE ULTIMATE WELLNESS FORMULA! 180 captabs, dose: 6 per day= 1 month supply = $39.95

Dear Friend:

Despite its tremendous resources, America leads the world in degenerativeillness. It is no wonder! Millions of people suffer from aweakened immune system, the body’s main defense against cancer,viral, bacterial and fungal infections. You live a fast paced, highstress lifestyle that often compromises your good intentions concerningdiet and exercise. Your immune system is under constant assault fromnoxious elements in our environment. You have been convinced of the vitalneed to supplement your diet with antioxidants and other essentialnutrients, but how do you make sense of all the hype that confrontsyou? Which nutrients are really important and how much should you take?What about the hot new product of the month? Who can you turn to with somany choices?

Preventive Therapeutics, Inc. (PTI) is proud to make available toyou a very special and unique dietary supplement, Dr. Burgstiner’sComplete Thymic Formula and Vitamin/Mineral Complex. This remarkableproduct combines comprehensive nutrition with herbal and glandularfactors to form a solid and wholesome foundation of nutritionalsupport. Formulated by a nutritional pioneer, this all natural formula isperfectly balanced with nutrients that are known to bolster your body’snatural defense system.

Complete Thymic Formula® is not a single ingredient wonder or a passingfad. It is a legacy of faith, obedience, and a distinguishedthirty-eight year medical practice devoted to preventive medicine andthe study of nutrition. It is manufactured under pharmaceuticalconditions with only the highest quality ingredients.Patented assimilation technology is responsible for its superiorabsorption qualities, but its most powerful component is not on thelabel. Enthusiastic supporters from all over the world are thanking Dr.Burgstiner for transforming their health while reducing the guess workin their supplement program.

The mission of PTI is to glorify God by enhancing your quality of lifethrough education and unsurpassed nutritional support. We back ourproducts with an unconditional satisfaction guarantee. If for anyreason you are not satisfied, just return the unused portion for a promptrefund. We hope that you will take advantage of this special no-riskoffer. Place your order today. you will be glad that you did!

Yours in Good Health, John M. Burgstiner, President.

# The Thymus Gland – Controller of Immunity

It is said that over sixty five million Americans suffer fromcompromised immunity. Supporting your immune system is the mostimportant step you can take in building resistance to illness andlimiting the natural effects of aging. According to Dr. MichaelT. Murray, nationally known lecturer and co-author of the bestseller Encyclopedia of Natural Medicine, “The most effectivemethod for maintaining or attaining a healthy immune system is supportingthe functions of the thymus gland…to a very large extent, thehealth of the thymus determines the health of the immune system.”1.

The thymus gland lies just beneath the breast bone. It is large in infantsand children and atrophies as we grow older. The thymus seedsthe body with immature T-cells, the white blood cells responsiblefor “cell-mediated immunity”. This gland secretes special chemicalscalled cytokines (ie.- interferon, interleukins) that influence thespecialization and migration of T-lymphocytes throughout the body. Thethymus also releases hormones that regulate immune function. Thesethymic hormones help immune cells to mature, “programming” them torecognize tissues as either self or invader. Recognizing the enemy is thefirst and likely most important step in the immune response.

As we age, the thymus shrinks as its role shifts from immune cellproduction to regulation of the immune response. Lower thymic hormonelevels in the blood are associated with depressed immunity, and aretypical of the elderly, individuals with chronic infections,auto-immune disorders, cancer and AIDS patients. The thymus is extremelysusceptible to free radical and oxidative damage caused by stress,radiation, poor diet, infection and chronic illness. People who haveundergone radiation, chemotherapy or other immune-suppressing treatmentsalso typically have low thymus function. Whatever the cause, depressedimmunity can lead to an increase in the frequency and severity ofcolds, fatigue, allergies, or the onset of opportunistic infections.

# Protecting Thymus Function

The thymus is quite responsive to environmental stimuli and thusis the beneficiary or the victim of the choices that we make every day. Inaddition to a healthy diet, adequate rest, water and exercise, we must learnto manage stress effectively. Antioxidants like vitamins Cand E, beta carotene and selenium help to protect the thymus from freeradicals, unstable molecules that damage our cells. Other nutrientssuch as zinc, vitamin B-6 and certain amino acids are importantbecause they are required for the production of thymic hormones.Vitamins and minerals serve as cofactors and catalysts in theenzymatic pathways that regulate our metabolism. As we age, manyessential vitamins and minerals become depleted and must be replaced.Their presence is essential for the proper working of the chemicalfactories within our cells.

# Glandular Therapy: Cells Help Like Cells

Glandular hormone replacement therapy is being accepted withgrowing enthusiasm by the established medical community. It is based uponthe use of animal glandular and organ substances to bolster thefunction of the human body’s organs and glands. Modern medicinereplaces the thyroid gland with thyroid hormone, the adrenal glandwith cortisone, the pancreas gland with insulin, and theovaries with estrogen and progesterone. However, physicians havenot routinely replaced the thymus gland. As your thymus shrinks andweakens with age, the most effective and direct way to stimulate it is byconsuming thymus tissue. Calf thymus has long been regarded as adelicacy, known throughout the world as “sweetbread”, but cookingdestroys many of the beneficial properties of the gland. Far moreeffective is to ingest raw, freeze dried thymus extract, which leavesthe thymic factors intact.

Thymic factors are said to be immune modulators. Thymic extractshave been shown to normalize the ratio of T-helper cells to suppressorcells whether the ratio is low as in AIDS, chronic infections andcancer, or high as found with allergies and autoimmune diseases likepsoriasis and rheumatoid arthritis.2. In other words, thymic factorsappear to influence the immune response up or down as needed!

Julian Whitaker, M.D, famous advocate of wellness and nutrition andauthor of the nationally syndicated newsletter, Health and Healing,is a long time proponent of thymic replacement therapy. In a recent reportin which he focused on the benefits of a single thymic protein, hestated “Even if you’re healthy, I recommend a maintenance dose ofthymic protein to support your immune function. Because decreasedthymic function, like falling hormone levels and gray hair, is aninevitable part of aging, it is a valuable addition to your generalanti-aging/longevity program.”

# THE ULTIMATE WELLNESS FORMULA!

Dr. Burgstiner’s Complete Thymic Formula (CTF) and Vitamin/Mineral Complexcombines cutting edge nutritional support with hormone replacementtherapy for the thymus gland. It is perhaps the most comprehensiveall natural dietary supplement available today. CTF contains asynergistic blend of herbs, essential vitamins, minerals and aminoacids, thymic and other glandular extracts, antioxidants, enzymes andwhole food extracts. This remarkable product is designed to providea solid and wholesome foundation of nutritional support while makingavailable factors that nourish and strengthen immune function.

SUPERIOR QUALITY

Complete Thymic Formula® is manufactured in an FDA/USDA approvedlaboratory practicing GMP (Good Manufacturing Practices). Stringentquality assurance procedures are maintained, and no solvents are usedin the manufacturing process. All raw materials are quarantined andtested for purity, potency and microbial content prior to use. Thethymic formula is further tested during production and again prior topackaging.

The vitamins and minerals in CTF are gluconated or chelated (attachedto protein) to ensure maximum bio-availability. This reduces theamount of undigested ingredients eliminated through bodily waste, a commonproblem with low cost vitamin/mineral supplements. Pharmaceutical gradethymus and other glandular extracts are harvested from clean U.S. orNew Zealand bovine herds only, and are hormone and antibioticfree.

SUPERIOR ABSORPTION

Complete Thymic Formula® uses a patented Controlled DeliverySystem(tm) to maximize the absorption and assimilation of nutrients,which are selectively delivered at the right time and place along thedigestive tract. In effect, this technology gives the formula an “innateintelligence”, recognizing that fat soluble nutrients are optimallyabsorbed along a certain section of the digestive tract and water solublenutrients along another. The spray/freeze dried materials are hydrolysated(made water soluble) for optimum absorption. The food factors have a naturalcoating that protects them in the acidic environment of the stomach,making them available in the small intestine where most absorption takesplace.

SUPERIOR PERFORMANCE

From raw materials to finished products, Preventive Therapeutics iscommitted to excellence in every detail. By far the most powerfulcomponent of any PTI product, however, is the spirit of intent withwhich it was created. Dr. Burgstiner had a refreshing disregard for thebusiness end of the natural products industry. His vision was toenhance the quality of life through education and truly outstandingnutritional support products. When he crafted Complete ThymicFormula®, he had one thing in mind…clinical efficacy.

Rooted in a holistic approach to wellness, the thymic formula seeks tobalance the immune system on a cellular level. The tremendous successof Complete Thymic Formula® was as inevitable as that of Dr.Burgstiner’s distinguished medical practice. Both grew out of hisphilosophy that “If you maintain normal physiology you can prevent diseaseand pathology!”

(References)

1 – Dr. Michael T. Murray: Ask the Doctor, published by VitalCommunications, 1999
2 – Cazzola P, Mazzanti P and Bossi G: in vivo modulating effect of a calfthymus acid lysate on human T lymphocyte subsets and CD4+/CD8+ ratio inthe course of different diseases. Curr Ther Res 42:1011-7, 1987. KouttabNM, Prada M and Cazzola P: Thymomodulin: biological properties andclinical applications. Medical Oncology and Tumor Pharmacotherapy 6:6-9,1989

## Captabs Contain

THYMIC FACTORS & GLANDULARS (Derived from Bovine Sources)

– Thymus Enzymatic polypeptide Fractions++ Containing Thymosin,Thymopoietin and (THF) Thymic Humoral Factor … 1,100 mg
– Thymus Extract … 100 mg
– Raw Spleen … 260 mg
– Raw Lymph … 130 mg
– Raw Bone Marrow … 130 mg
– Raw Pituitary … 20 mg

VITAMIN/MINERAL NUTRIENTS

– Vitamin A – (Beta Carotene)- 5,000 IU
– Vitamin D – (Colecalciferol) – 400 IU
– Vitamin C – (Ascorbic Acid, buffered & esterified) – 1,000 mg
– Vitamin E – (d-Alpha tocopherol succinate) – 460 IU
– Folic Acid – 400 mcg
– Vitamin B-1 – (Thiamine Mononitrate) – 85 mg
– Vitamin B-2 – (Riboflavin) – 25 mg
– Niacinamide – 50 mg
– Vitamin B-6 – (Pyridoxine Hydrochloride) – 25 mg
– Vitamin B-12 – (Cyanocobalamin) – 50 mcg
– Biotin – 300 mcg
– Pantothenic Acid – (Calcium Pantothenate) – 50 mg
– Calcium – (Carbonate) – 150 mg
– Iodine – (Kelp) – 150 mcg
– Magnesium – (Gluconate) – 100 mg
– Copper – (Proteinate/Gluconate) – 2,6 mg
– Zinc – (Proteinate/Gluconate) – 45 mg
– Selenium – (Proteinate/Chelate) – 165 mcg
– Potassium – (Gluconate) – 50 mg
– Manganese – (Gluconate) – 5 mg
– Chromium – (Picolinate) – 50 mcg
– Boron – 1 mg

HERBS AND OTHER INGREDIENTS

– Hesperidin – 5 mg
– Inositol – 250 mg
– Citrus Bioflavonoids – 25 mg
– Choline – (Bitartrate) – 100 mg
– Betaine HCL – 25 mg
– Octacosanol – 375 mcg
– PABA – (Para Amino Benzoic Acid) – 25 mg
– Rutin – 25 mg
– Trypsin – (1:75) – 50 mg
– Bromelain – (1:1200MCU) – 100 mg
– Papain – (600) – 40 mg
– Echinacea Angustifolia – (Angustifolia Root Extract) – 600 mg
– Iris Versicolor Extract – (Blue Flag Root Extract) – 260 mg
– Hydrastis Canadensis – (Golden Seal Root Extract) – 168 mg
– L-Lysine – 525 mg
– Amino Acid Complex + – 25 mg

# Preparation:

This product is prepared in a natural base containing: Alfalfa leafextract, Deoxyribonucleic acid, Brewers yeast, Wheat germ extract,ribonucleic acid, Watercress, Lecithin extract, Glutamic acid, Applepectin, Yogurt culture, Acidophilus, Kelp and Bone meal.

SUGAR, STARCH, SALT AND PRESERVATIVE FREE AND NATURAL PROTECTIVE COATINGUTILIZED.

# Our Company

Preventive Therapeutics, Inc. was founded by Carson B.Burgstiner M.D. in 1996 to enhance his patients’ quality of lifethrough education and outstanding nutritional support products. PTI iscommitted to providing our customers with accurate information on theimportance of prevention and nutritional supplementation which isessential to maintaining overall wellness, fitness and longevity.We will supply only the highest quality nutritional support products thatfurther the philosophy of Dr. Burgstiner that:

“If you maintain normal physiology you can prevent disease andpathology!”

Dr. Burgstiner was a nutritional pioneer and Board-Certified OB-GYNwho practiced preventive medicine in Savannah, Georgia for 38 years. Hewas past President of the Medical Association of Georgia and pastVice-Chairman of the Georgia delegation to the AMA. Dr. Burgstinerwas also a Fellow of the American College of OB-GYN, a Fellow of theAmerican College of Surgeons, a Fellow of the American College ofInternational Surgeons, and a Fellow of the American College ofPreventive Medicine. In 1997 he was inducted into the Universityof Miami School of Medicine Hall of Fame as one of only eightdistinguished alumni since 1961.

Dr. Burgstiner dedicated his practice to understanding and promotingthe role of proper nutrition in maintaining good health. A publishedauthor and dynamic speaker, his advice was sought out by patients andcolleagues throughout the world.

Dr. Burgstiner received the ultimate reward for his passion and faith in1997 when God called him home, but he left behind an incredible legacythat continues to transform the lives of people around the globe.The job of carrying on with this legacy was delivered into the capablehands of John Burgstiner, who shares his father’s passion for thesuffering and thirst for knowledge:

“As any of his adoring patients will testify, my father was given anunusual capacity for loving others and amazing discernment into theirhealth challenges. His message was way ahead of its time. He saw PTI as aplatform to speak truth to those who have ears to hear, to expose theenemy’s tactics of slowly stealing away our health and vitality throughthe poor choices we make every day. It is both humbling and exhilaratingto have been nourished by this fountain of wisdom and to share it with theworld.”

John M. Burgstiner, President and CEO, Preventive Therapeutics, Inc.

## How serious is hepatitis? http://www.vitacost.com/science/hn/Concern/Hepatitis.htm
or at http://www.tmh.org/library/healthguide/en-us/Cam/topic.asp?hwid=hn-1027000

Hepatitis is a fairly common liver disease caused by long-termalcohol abuse, infection, or exposure to chemicals and drugs. Occasionally,hepatitis is severe, or even fatal, so it is important to seek professionalcare for diagnosis and treatment.

Warning signs include:
# Loss of appetite, malaise, nausea and vomiting, and fever
# Darkening of the urine and jaundice (yellowing of the skin and the whitesof the eyes)

Self-care for hepatitis can be approached in a number of ways-but it can behard to know just where to start. To make it easier, our doctorsrecommend trying these simple steps first:
· See a doctor
· Get evaluated to determine the cause and best treatment for your condition
· Reduce damage with milk thistle
· Take a standardized extract providing 420 mg a day of silymarin to helpthe liver
· Check out SAMe
· 1,600 mg a day of SAMe (s-adenosyl-l-methionine) may help resolveblocked bile flow
· Try phyllanthus
· 900 to 2,700 mg a day may be beneficial for people with hepatitis B

These recommendations are not comprehensive and are not intended to replacethe advice of your doctor or pharmacist. Continue reading the full hepatitisarticle for more in-depth, fully-referenced information on medicines,vitamins, herbs, and dietary and lifestyle changes that may be helpful.

# About hepatitis
Hepatitis is a liver disease that can result from long-term alcohol abuse http://www.vitacost.com/science/hn/Concern/Alcohol.htm , infection http://www.vitacost.com/science/hn/Concern/Infection.htm , orexposure to various chemicals and drugs. Because hepatitis is potentiallyvery dangerous, a healthcare professional should be involved in itstreatment.

# What are the symptoms of hepatitis?
Acute viral hepatitis varies from a minor flu-like illness to anoverwhelming infection resulting in liver failure and death. The earlyphase is characterized by loss of appetite, malaise, nausea and vomiting,and fever. Signs include a darkening of the urine and jaundice (yellowing ofthe skin and whites of the eyes). Chronic hepatitis may be asymptomatic, ormay manifest as malaise, fatigue, loss of appetite and a low-grade fever.

# Medical treatments
Therapy for chronic hepatitis B and C is evolving and may includeinterferon http://www.vitacost.com/science/hn/Drug/Interferon.htm (PEG-Intron®, Roferon-A®, Intron A®, Infergen®), antiviral http://www.vitacost.com/science/hn/Drug/Antivirals.htm (Rebetrol®), and immune-modulating drugs. Autoimmune hepatitis is usuallytreated with corticosteroids http://www.vitacost.com/science/hn/Drug/Corticosteroids.htm , such asprednisone (Deltasone®).

Acute hepatitis generally resolves without medications. Treatment ofchronic hepatitis includes cessation of causative agents like alcohol. Inthe late stages of certain types of hepatitis (not hepatitis B, generally),liver transplantation may be required to preserve life.

# Lifestyle changes that may be helpful
Avoiding alcohol is the most obvious way to avoid the liver damage itcauses.

A variety of prescription drugs can, on rare occasions, cause hepatitis, ascan large amounts of niacin http://www.vitacost.com/science/hn/Supp/Vitamin_B3.htm or niacinamide (forms of vitamin B3). Excessive intake of acetaminophen http://www.vitacost.com/science/hn/Drug/Acetaminophen.htm or otherpainkillers can damage the liver, so excessive intake of these drugs shouldbe avoided. People with hepatitis C who failed to respond to interferontherapy have been found to have a higher amount of iron http://www.vitacost.com/science/hn/Supp/Iron.htm within the liver.1. People with hepatitis C should, therefore, avoidiron supplements. People with any type of hepatitis should ask theirphysician whether any medication they are taking poses a risk to the liver.

For infectious (viral) hepatitis, good hygiene is necessary to avoidspreading the infection. The hepatitis A virus can be spread very easilythrough food that is handled by infected individuals; therefore, people withhepatitis A should wash their hands very carefully after using the restroomand should not handle food at work. The hepatitis viruses B and C are bothtransmitted by blood and sexual contact.

## Nutritional supplements that may be helpful

Catechin, a flavonoid http://www.vitacost.com/science/hn/Supp/Flavonoids.htm ,has helped people with acute viral hepatitis,(2) as well as individuals withchronic hepatitis,(3) though not all trials have found a benefit.(4) Atypical amount used in successful trials is 500-750 mg three times perday. Although catechin is found in several plants, none containsufficient amounts to reach the level used in the trials; thus, catechinsupplements are needed. However, because of its potential to causeside effects on rare occasions,(5) catechin should be used only undermedical supervision.

Proteins from the thymus gland, an important part of the immunesystem http://www.vitacost.com/science/hn/Concern/Immune_Function.htm , mayhave a beneficial effect in people with chronic hepatitis B. Initial trialsdone in Poland used injected thymus proteins with good results.(6)Further trials using a variety of thymus extracts http://www.vitacost.com/science/hn/Supp/Thymus_Extracts.htm by mouthhave found that they can improve blood tests that measure liver damage aswell as improve immune cell numbers.(7,8) Preliminary evidence also suggeststhese extracts may help patients with hepatitis C.(9) The standardrecommendation for supplementation is 200 mg three times per day ofcrude extracts or 40 mg three times per day of purified proteins.

S-adenosylmethionine http://www.vitacost.com/science/hn/Supp/SAMe.htm (SAMe) (1,600 mg/day orally or 800 mg/day intravenously) has been shown toaid in the resolution of blocked bile flow (cholestasis), a commoncomplication of chronic hepatitis. (10,11)

– Taking 3 grams per day of phosphatidylcholine http://www.vitacost.com/science/hn/Supp/Lecithin.htm (found in lecithin) was found to be beneficial in one investigation ofpeople with chronic hepatitis B. (12) Signs of liver damage on biopsy weresignificantly reduced in this trial.

Vitamin E http://www.vitacost.com/science/hn/Supp/Vitamin_E.htm levels have been shown to be low in people with hepatitis,(13) as well as inthose who later develop liver cancer from long-standing hepatitis.(14)Vitamin E levels in the liver may also be decreased in some people withhepatitis. (15) In a controlled trial of individuals with hepatitis B, 600IU of vitamin E per day for nine months resulted in all signs ofhepatitis disappearing in five of twelve people. (16) In a preliminary trialof adults with hepatitis C, administering 1,200 IU per day of vitamin Efor eight weeks appeared to reduce liver damage to some extent. (17) In apreliminary trial of people with hepatitis C, 544 IU of vitamin E perday for 24 weeks improved the response to interferon /antioxidant http://www.vitacost.com/science/hn/Supp/Antioxidants.htm therapy,although the results did not reach statistical significance. (18) However,in children with viral hepatitis, daily injections of vitamin E (300 IU) forseven days did not produce any benefit. (19)

Vitamin C http://www.vitacost.com/science/hn/Supp/Vitamin_C.htm in the amount of 2 grams per day was reported in a preliminary trialto prevent hepatitis infection in individuals receiving bloodtransfusions.(20) This report was followed up by a double-blind trial,in which 3.2 grams per day of vitamin C was reported to have no protectiveeffect against post-transfusion hepatitis.(21) (However, in the lattertrial, vitamin C actually reduced the incidence of hepatitis by 29%,although this reduction was not statistically significant.) An older trialsuggested that injections of vitamin C may be helpful in treating viralhepatitis.(22)
A potent antioxidant combination may protect the liver from damage in peoplewith hepatitis C, possibly decreasing the necessity for a liver transplant.In a preliminary trial,(23) three people with liver cirrhosis http://www.vitacost.com/science/hn/Concern/Liver_Cirrhosis.htm andesophageal varices (dilated veins in the esophagus that can rupture andcause fatal bleeding) caused by hepatitis C received a combination of Alphalipoic acid http://www.vitacost.com/science/hn/Supp/Alpha_Lipoic_Acid.htm (300mg twice daily), silymarin (from milk thistle http://www.vitacost.com/science/hn/Herb/Milk_Thistle.htm; 300 mg three times daily), and selenium http://www.vitacost.com/science/hn/Supp/Selenium.htm (selenomethionine; 200 mcg twice daily). After five to eight months oftherapy that included other “supportive supplements,” such as vitamin Cand B vitamins http://www.vitacost.com/science/hn/Supp/Vitamin_B_Complex.htm , allthree people had significant improvements in their liver functionand overall health. Larger clinical trials are needed to confirm these promisingpreliminary results.

Vitamin B12 http://www.vitacost.com/science/hn/Supp/Vitamin_B12.htm (with or without folic acid http://www.vitacost.com/science/hn/Supp/Folic_Acid.htm )has been reported in trials from the 1950s to help some people withhepatitis. (24,25) Vitamin B12 injections are likely to be morebeneficial than oral administration, though 1,000 mcg (taken orally) eachday can also be supplemented.

– In a preliminary report, three patients with chronic hepatitis B had animprovement in the severity of their hepatitis after taking 100 mg ofthiamine http://www.vitacost.com/science/hn/Supp/Vitamin_B1.htm (vitamin B1) per day. (26)

– In a preliminary trial, supplementation with betaine http://www.vitacost.com/science/hn/Supp/Betaine.htm (20 grams per day) for 12 months improved signs of liver inflammation inseven patients with nonalcoholic steatohepatitis, a type of liverinflammation. No significant side effects were seen. (27)

– Supplementation with 17 mg of zinc twice a day (in the form of a zinccomplex of L-carnosine) enhanced the response to interferon therapy inpatients with chronic hepatitis C, in a preliminary trial.(28) It is notknown whether this benefit was due primarily to the zinc or the carnosinehttp://www.vitacost.com/science/hn/Supp/Carnosine.htm , or whetherother forms of zinc would have the same effect.

– A preliminary trial found 24 grams per day of whey protein http://www.vitacost.com/science/hn/Supp/Whey_Protein.htm improved blood measures of liver dysfunction in people with hepatitisB, but not those with hepatitis C.(29)

# Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects orinteractions.

## Herbs that may be helpful

– Preliminary trials have shown that the bupleurum http://www.vitacost.com/science/hn/Herb/Bupleurum.htm -containingformula sho-saiko– to can help reduce symptoms and blood liver enzymelevels in children and adults with chronic active viral hepatitis.(30,31,32,33) Most of theses trials were in people with hepatitis Binfection, though one preliminary trial has also shown a benefit in peoplewith hepatitis C. (34) Sho-saiko-to was also found, in a large preliminarytrial to decrease the risk of people with chronic viral hepatitis developingliver cancer. However, people who had a sign of recent hepatitis B infectionwere not as strongly protected in this trial. (35) The usual amount ofsho-saiko-to used is 2.5 grams three times daily. Sho-saiko-toshould not be used together with interferon drug therapy as it may increaserisk of pneumonitis – a potentially dangerous inflammation in the lungs.(36)

Cordyceps http://www.vitacost.com/science/hn/Herb/Cordyceps.htm has repeatedly been shown effective in clinical trials at reducingfibrosis and improving liver and immune function in people withchronic hepatitis B, including those with cirrhosis. (37,38,39) The usualamount taken is 3 to 4.5 grams twice daily as capsules or simmeredfor 10 to 15 minutes in water to make tea.

Silymarin, the flavonoid extracted from milk thistle, hasbeen studied for treating all types of liver disease. The standard amountused in most trials has delivered 420 mg of silymarin per day. For acutehepatitis, double-blind trials have shown mixed results. (40,41) Apreparation of silymarin and phosphatidylcholine http://www.vitacost.com/science/hn/Supp/Lecithin.htm was reported to help sufferers of chronic viral hepatitis. One smallpreliminary trial found that at least 420 mg of silymarin was necessary eachday.(42) A controlled trial found that silymarin decreased liver damage.(43) One trial has suggested that silymarin may be more effective forhepatitis B as opposed to hepatitis C. (44)
Recent findings have shown that silymarin has the ability to blockfibrosis, a process that contributes to the eventual development ofcirrhosis in persons with inflammatory liver conditions secondary to alcoholabuse or hepatitis. (45) While there are no published clinical trials inpeople with hepatitis C to date, this action makes milk thistle extractpotentially attractive as a supportive treatment for thecondition-particularly for those that have not responded to standard drugtherapy. The effectiveness of silymarin (particularly its antifibroticactions) needs to be studied in larger numbers of persons with hepatitis Cto determine whether it is an effective treatment for this condition.

Phyllanthus http://www.vitacost.com/science/hn/Herb/Phyllanthus.htm (Phyllanthusamarus), an Ayurvedic http://www.vitacost.com/science/hn/Therapy/Ayurvedic_Herbs.htm herb,has been studied primarily in carriers of the hepatitis B virus, as opposedto those with chronic active hepatitis. In one trial, administering thisherb for 30 days appeared to eliminate the hepatitis B virus in 22 of 37cases (59%). (46) However, other trials have failed to confirm abeneficial effect of Phyllanthus amarus against hepatitis B. (47,48) A WestIndian species, Phyllanthus urinaria (not widely available in theUnited States or Europe), has achieved much better results thanIndian Phyllanthus amarus.(49) Thus, the specific plant species used mayhave a significant impact on the results. The amount of phyllanthus used inclinical trials has ranged from 900-2,700 mg per day.

– A crude extract of red peony http://www.vitacost.com/science/hn/Herb/Peony.htm root was shown in a small, preliminary trial to reduce cirrhosis insome people with chronic viral hepatitis. (50) Other preliminary trialspublished in Chinese demonstrated that red peony root was helpful (byreducing liver enzyme levels or symptoms or both) for people withviral hepatitis. (51)

– One of the active constituents in licorice http://www.vitacost.com/science/hn/Herb/Licorice.htm ,glycyrrhizin, is sometimes used in Japan as an injected therapy forhepatitis B and C. (52,53) Glycyrrhizin also blocks hepatitis Avirus from replicating in test tubes. (54) One preliminary trial found thatuse of 2.5 grams licorice three times per day providing 750 mgglycyrrhizin was superior to the drug inosine polyIC in helping peoplewith acute and chronic viral hepatitis. (55) Because glycyrrhizin cancause high blood pressure http://www.vitacost.com/science/hn/Concern/Hypertension.htm andother problems, it should only be taken on the advice of a healthcarepractitioner.

– A series of cases of acute viral hepatitis were reported by one group inIndia, showing picrorhiza http://www.vitacost.com/science/hn/Herb/Picrorhiza.htm ,combined with a variety of minerals, to be helpful in hastening recovery.(56) A variety of similar reports have appeared in the Indian literatureover the years, although no double-blind clinical trials have yet beenpublished. Between 400 and 1,500 mg of powdered, encapsulated picrorhizaper day has been used in a variety of trials. Andrographis http://www.vitacost.com/science/hn/Herb/Andrographis.htm , another traditionalIndian herb, has shown preliminary benefit for people with chronicviral hepatitis. (57)

– Preliminary human research demonstrates some efficacy for the mushroomreishi http://www.vitacost.com/science/hn/Herb/Reishi.htm in treatingchronic hepatitis B; however, additional clinical trials are needed. (58)

– An uncontrolled trial found that shiitake http://www.vitacost.com/science/hn/Herb/Shiitake.htm formulations containing Lentinus edodes mycelium (LEM- the powderedmycelium of the mushroom before the cap and stem grow) may help decreaseblood markers of liver inflammation. (59) One marker of hepatitis Binfection in the blood (HBeAg) disappeared in 14% of the patients in thistrial. Given the preliminary nature of the research, more information isneeded to determine if LEM is effective for hepatitis.
– Modern Chinese research suggests that compounds called lignans inschisandra http://www.vitacost.com/science/hn/Herb/Schisandra.htm promote regeneration of liver tissue that has been damaged by harmfulinfluences, such as hepatitis viruses or alcohol. In a controlled trial,Chinese patients with chronic viral hepatitis were given 500 mgschisandra extract three times daily or liver extract and B vitamins.(60) Among those given schisandra, serum glutamic pyruvic transaminase(SGPT) levels declined to normal levels in 68% compared to 44% of thecontrol group. Lower SGPT levels suggest less liver inflammation. There wasalso a reduction in symptoms such as insomnia http://www.vitacost.com/science/hn/Concern/Insomnia.htm ,fatigue, loose stools http://www.vitacost.com/science/hn/Concern/Diarrhea.htm ,and abdominal tension in the schisandra group. A preliminary trial in 5,000people with various types of hepatitis found normalizations in SGPT orrelated liver enzymes in 75% of cases using an unspecified amount ofschisandra. (61)

– Early clinical trials in China suggest astragalus http://www.vitacost.com/science/hn/Herb/Astragalus.htm root might benefit people with chronic viral hepatitis, though it may takeone to two months to see results. (62) Textbooks on Chinese herbs recommendtaking 9-15 grams of the crude herb per day in decoction form. Adecoction is made by boiling the root in water for a few minutes and thenbrewing the tea.

– Another Chinese herb, Chinese scullcap http://www.vitacost.com/science/hn/Herb/Scullcap_Chinese.htm , mightbe useful for liver infections. However, the research on this is generallyof low quality. (63)

# References
1. Di Bisceglie AM, Bonkovsky HL, Chopra S, et al. Iron reduction as anadjuvant to interferon therapy in patients with chronic hepatitis C who havepreviously not responded to interferon: a multicenter, prospective,randomized, controlled trial. Hepatology 2000;32:135-8.
2. Blum AL, Doelle W, Kortum K, et al. Treatment of acute viral hepatitiswith (+)-cyanidanol-3. Lancet 1977;2:1153-5.
3. Suzuki H, Yamamoto S, Hirayama C, et al. Cianidanol therapy forHBs-antigen-positive chronic hepatitis: a multicentre, double-blind study.Liver 1986;6:35-44.
4. Bar-Meir S, Halpern Z, Gutman M, et al. Effect of (+)-cyanidanol-3 onchronic active hepatitis: A double blind controlled trial. Gut1985;26:975-9.
5. Conn HO. Cyanidanol: will a hepatotrophic drug from Europe go west?Hepatology 1983;3:121-3.
6. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). MedOncol Tumor Pharmacother 1989;6:31-43 [review].
7. Galli M, Crocchiolo P, Negri C, et al. Attempt to treat acute type Bhepatitis with an orally administered thymic extract (thymomodulin):Preliminary results. Drugs Exp Clin Res 1985;11:665-9.
8. Bortolotti F, Cadrobbi P, Crivellaro C, et al. Effect of an orallyadministered thymic derivative, thymomodulin, in chronic type B hepatitis inchildren. Curr Ther Res 1988;43:67-72.
9. Civeira MP, Castilla A, Morte S, et al. A pilot study of thymus extractin chronic non-A, non-B hepatitis. Aliment Pharmacol Ther 1989;3:395-401.
10. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for thetreatment of intrahepatic cholestasis of pregnancy. Results of a controlledclinical trial. Hepatogastroenterology 1990;37 Suppl 2:122-5.
11. Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine inthe symptomatic treatment of intrahepatic cholestasis. A double-blind,placebo-controlled study. Gastroenterology 1990;99:211-5.
12. Jenkins PJ, Portmann BP, Eddleston AL, Williams R. Use ofpolyunsaturated phosphatidylcholine in HBsAg negative chronic activehepatitis: Results of prospective double-blind controlled trial. Liver1982;2:77-81.
13. Von Herbay A, Stahl W, Niederau C, et al. Diminished plasma levels ofvitamin E in patients with severe viral hepatitis. Free Radic Res1996;25:461-6.
14. Pan WH, Wang CY, Huang SM, et al. Vitamin A, vitamin E or beta-carotenestatus and hepatitis B-related hepatocellular carcinoma. Ann Epidemiol1993;3:217-24.
15. Mezes M, Par A, Nemeth P, Javor T. Studies of the blood lipid peroxidestatus and vitamin E levels in patients with chronic active hepatitis andalcoholic liver disease. Int J Clin Pharmacol Res 1986;6:333-8.
16. Andreone P, Gramonzi A, Bernardi M. Vitamin E for chronic hepatitis B.Ann Intern Med 1998;128:156-7.
17. Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of theeffects of d-alpha-tocopherol on hepatic stellate cell activation in chronichepatitis C. Gastroenterology 1997;113:1069-73.
18. Look MP, Gerard A, Rao GS, et al. Interferon/antioxidant combinationtherapy for chronic hepatitis C-a controlled pilot trial. Antiviral Res1999;43:113-22.
19. Yurdakok M, Kanra G. Vitamin E therapy in viral hepatitis. MikrobiyolBul 1986;20:91-4 [in Turkish].
20. Morishige F, Murata A. Vitamin C for prophylaxis of viral hepatitis B intransfused patients. J Int Acad Prev Med 1978;5(1):54-8.
21. Knodell RG, Tate MA, Akl BF, Wilson JW. Vitamin C prophylaxis for posttransfusion hepatitis: lack of effect in a controlled trial. Am J Clin Nutr1981;34:20-3.
22. Baur H, Staub H. Treatment of hepatitis with infusions of ascorbic acid:comparison with other therapies. JAMA 1954;156:565 [abstract].
23. Berkson BM. A conservative triple antioxidant approach to the treatmentof hepatitis C. Combination of Alpha lipoic acid (thioctic acid), silymarin,and selenium: three case histories. Med Klin 1999;94 Suppl 3:84-9.
24. Campbell RE, Pruitt FW. Vitamin B12 in the treatment of viral hepatitis.Am J Med Sci 1952;224:252-62.
25. Campbell RE, Pruitt FW. The effect of vitamin B12 and folic acid in thetreatment of viral hepatitis. Am J Med Sci 1955;229:8-15.
26. Wallace AE, Weeks WB. Thiamine treatment of chronic hepatitis Binfection. Am J Gastroenterol 2001;96:864-8.
27. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising newagent for patients with nonalcoholic steatohepatitis: results of a pilotstudy. Am J Gastroenterol 2001;96:2711-17.
28. Takagi H, Nagamine T, Abe T, et al. Zinc supplementation enhances theresponse to interferon therapy in patients with chronic hepatitis C. J ViralHepat 2001;8:367-71.
29. Watanabe A, Okada K, Shimizu Y, et al. Nutritional therapy of chronichepatitis by whey protein (non-heated). J Med 2000;31:283-302.
30. Hirayama C, Okumura M, Tanikawa K, et al. A multicenter randomizedcontrolled clinical trial of Shosaiko-to in chronic active hepatitis.Gastroent Jap 1989;24:715-9.
31. Fujiwara K, Ohta Y, Ogata I, et al. Treatment trial of traditionalOriental medicine in chronic viral hepatitis. In: Ohta Y (ed) New Trends inPeptic Ulcer and Chronic Hepatitis: Part II. Chronic Hepatitis. Tokyo:Excerpta Medica, 1987, 141-6.
32. Tajiri H, Kozaiwa K, Osaki Y, et al. The study of the effect ofsho-saiko-to on HBeAg clearance in children with chronic HBV infection andwith abnormal liver function tests. Acta Paediatr Jpn 1991;94:1811-5.
33. Gibo Y, Nakamura Y, Takahashi N, et al. Clinical study of sho-saiko-totherapy for Japanese patients with chronic hepatitis C (CH-C). Prog Med1994;14:217-9.
34. Gibo Y, Nakamura Y, Takahashi N, et al. Clinical study of sho-saiko-totherapy for Japanese patients with chronic hepatitis C (CH-C). Prog Med1994;14:217-9.
35. Oka H, Yamamoto S, Kuroki T, et al. Prospective study of chemopreventionof hepatocellular carcinoma with sho-saiko-to (TJ-9). Cancer 1995;76:743-9.
36. Mizushima Y, Oosaki R, Kobayashi M. Clinical features of pneumonitisinduced by herbal drugs. Phytother Res 1997;11:295-8.
37. Gong HY, Wang KQ, Tang SG. Effects of Cordyceps sinensis on T lymphocytesubsets and hepatofibrosis in patients with chronic hepatitis B. Hunan Yi KeDa Xue Bao 2000;25:248-50 [in Chinese].
38. Zhou L, Yang W, Xu Y, et al. Short-term curative effect of culturedCordycepssinensis (Berk.) Sacc. Mycelia in chronic hepatitis B. ZhongguoZhong Yao Za Zhi 1990;15:53-5, 65 [in Chinese].
39. Zhu JL, Liu C. Modulating effects of extractum semen persicae andcultivated cordyceps hyphae on immuno-dysfunction of inpatients withposthepatitic cirrhosis. Zhongguo Zhong Xi Yi Jie He Za Zhi1992;12:207-9,195 [in Chinese].
40. Magliulo E, Gagliardi B, Fiori GP. Results of a double blind study onthe effect of silymarin in the treatment of acute viral hepatitis carriedout at two medical centres. Med Klin 1978;73:1060-5 [in German].
41. Bode JC, Schmidt U, Durr HK. Silymarin for the treatment of acute viralhepatitis? Report of a controlled trial. Med Klin 1977;72:513-8 [in German].
42. Vailati A, Aristia L, Sozze E, et al. Randomized open study of thedose-affect relationship of a short course of IdB 1016 in patients withviral or alcoholic hepatitis. Fitoterapia 1993;64:219-27.
43. Buzzelli G, Moscarella S, Giusti A, et al. A pilot study on the liverprotective effect of silybinphosphatidylcholine complex (IdB 1016) inchronic active hepatitis. Int J Clin Pharmacol Ther Toxicol 1993;31:456-60.
44. Lirussi F, Okolicsanyi L. Cytoprotection in the nineties: experiencewith ursodeoxycholic acid and silymarin in chronic liver disease. ActaPhysiol Hung 1992;80:363-7.
45. Schuppan D, Strösser W, Burkard G, Walosek G. Legalon® lessens fibrosingactivity in patients with chronic liver diseases. Zeits Allgemeinmed1998;74:577-84.
46. Thyagarajan SP, Subramian S, Thirunalasundari T, et al. Effects ofPhyllanthus amarus on chronic carriers of hepatitis B virus. Lancet1988;2:764-6.
47. Doshi JC, Vaidya AB, Antarkar DS, et al. A two-stage clinical trial ofPhyllanthus amarus in hepatitis B carriers: Failure to eradicate the surfaceantigen. Indian J Gastroenterol 1994;13:7-8.
48. Leelarasamee A, Trakulsomboon S, Maunwongyathi P, et al. Failure ofPhyllanthus amarus to eradicate hepatitis B surface antigen from symptomlesscarriers. Lancet 1990;335:1600-1.
49. Wang M, Cheng H, Li Y, et al. Herbs of the genus Phyllanthus in thetreatment of chronic hepatitis B: observations with three preparations fromdifferent geographical sites. J Lab Clin Med 1995;126:350-2.
50. Yang DG. Comparison of pre- and post-treatmental hepatohistology withheavy dosage of Paeonia rubra on chronic active hepatitis caused liverfibrosis. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih 1994;14:195,207-9 [inChinese].
51. Wang CB, Chang AM. Plasma thromboxane B2 changes in severe icterichepatitis treated by traditional Chinese medicine-dispelling the pathogenicheat from blood, promoting blood circulation and administrating large dosesof radix Paeoniae-a report of 6 cases. Chung Hsi I Chieh Ho Tsa Chih1985;5:322,326-8 [in Chinese].
52. Suzuki H, Ohta Y, Takino T, et al. Effects of glycyrrhizin onbiochemical tests in patients with chronic hepatitis. Double blind trial.Asian Med J 1983;26:423-38.
53. Yasuda K, Hino K, Fujioka S, et al. Effects of high dose therapy withStronger Neo-Minophagen C (SNMC) on hepatic histography in non-A, non-Bchronic active hepatitis. In Viral Hepatitis C, D, E, ed. T Shikata, RHPurcell, T Uchida. Amsterdam: Excerpta Medica, 1991, 205-9.
54. Crance JM, L’eveque F, Biziagos E, et al. Studies on mechanism of actionon glycyrrhizin against hepatitis A virus replication in vitro. AntiviralRes 1994;23:63-76.
55. Su XS, Chen HM, Wang LH, et al. Clinical and laboratory observation onthe effect of glycyrrhizin in acute and chronic viral hepatitis. J Trad ChinMed 1984;4:127-32.
56. Chaturvedi GN, Singh RH. Jaundice of infectious hepatitis and itstreatment with an indigenous drug, Picrorhiza kurrooa [sic]. J Res Ind Med1966;1:1-13.
57. Chaturvedi GN, Tomar GS, Tiwari SK, Singh KP. Clinical studies onkalmegh (Andrographis paniculata) in infective hepatitis. J Int InstAyurveda 1983;2:208-11.
58. Hobbs, C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995,96-107.
59. Harada T, Kanetaka T, Suzuki H, Suzuki K. Therapeutic effect of LEM(extract of cultured Lentinus edodes mycelia) against HBeAg-positive chronichepatitis B. Gastroenterol Int 1988;1(suppl 1):abstract 719.
60. Liu KT. Studies on fructus Schisandrae chinensis. Annex 12: Studies onfructus Schisandrae chinensis. Plenary lecture, World Health OrganizationSeminar on the Use of Medicinal Plants in Health Care, Sept 1977, Tokyo,Japan. In: WHO Regional Office for the Western Pacific Final Report, Manila,1977, 101-12.
61. Chang HM, But P (eds). Pharmacology and Applications of Chinese MateriaMedica vol 1. Singapore: World Scientific, 1986.
62. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: SpringerVerlag, 1992.
63. Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs:Monographs for the Western Herbal Practitioner. Warwick, Australia: 1996.

## Thymus Extracts to cure Hepatitis, http://www.vitacost.com/science/hn/Supp/Thymus_Extracts.htm

What are they?

Thymus extracts are extracts derived from the thymus glands usually ofyoung calves (bovine). The thymus is one of our major immunesystem glands http://www.vitacost.com/science/hn/Concern/Immune_Function.htm . Itis composed of two soft pinkish-gray lobes lying in bib-like fashionjust below the thyroid gland and above the heart. To a large extent,the health of the thymus determines the health of the immune system. Thethymus is responsible for many immune system functions, includingthe production of T lymphocytes, a type of white blood cell responsible for”cell-mediated immunity.” Cell-mediated immunity refers to immune mechanismsnot controlled or mediated by antibodies. Cell-mediated immunity isextremely important in the resistance to infection by certain bacteria,yeast (including Candida albicans), fungi, parasites http://www.vitacost.com/science/hn/Concern/Parasites.htm, and viruses (including herpes simplex http://www.vitacost.com/science/hn/Concern/Genital_Herpes.htm ,Epstein-Barr, and the viruses that cause hepatitis http://www.vitacost.com/science/hn/Concern/Hepatitis.htm). Cell-mediated immunity is also critical in protecting against thedevelopment of cancer http://www.vitacost.com/science/hn/Concern/Cancer_Diet.htm ,allergies http://www.vitacost.com/science/hn/Concern/Allergies.htm, and autoimmune disorders such as rheumatoid arthritis http://www.vitacost.com/science/hn/Concern/Rheumatoid_Arthritis.htm .The thymus gland also releases several hormones, such as thymosin,thymopoeitin, and serum thymic factor, that regulate many immunefunctions.

The oral calf thymus extract that has been studied scientifically isspecially prepared to concentrate small protein-like molecules(polypeptides). This extract (known as Thymomodulin®) has been showneffective in preventing recurrent upper respiratory tract infections.

Preliminary studies suggest that Thymomodulin may also be helpful in (1)improving one of the T-cell defects in patients with humanimmunodeficiency virus infection (HIV http://www.vitacost.com/science/hn/Concern/HIV_Support.htm -thevirus that causes AIDS); (2) treating acute and chronic hepatitis Binfections; (3) restoring the number of peripheral white blood cells incancer patients undergoing chemotherapy or radiation; and (4) relievingallergies http://www.vitacost.com/science/hn/Concern/Allergies.htm, including asthma http://www.vitacost.com/science/hn/Concern/Asthma.htm ,hay fever http://www.vitacost.com/science/hn/Concern/Hayfever.htm ,and food allergies, in children.(1,2) The effectiveness of Thymomodulin inthese conditions may be the result of improved thymus gland activity, or itmay be due to the presence of hormones or other biologically activesubstances in the extract.

The ability of Thymomodulin to improve immune function and reduce thenumber of recurrent infections http://www.vitacost.com/science/hn/Concern/Infection.htm has been shown in double-blind studies of children and adults with ahistory of recurrent respiratory-tract infections.(3,4,5,6,7) Thymomodulinhas also been shown in a double-blind study to improve immune function incases of exercise-induced immune suppression. In addition, preliminarystudies have shown the extract to improve immune function in people withdiabetes http://www.vitacost.com/science/hn/Concern/Diabetes.htm and in elderly people.(8,9,10,11) (Extreme exercise http://www.vitacost.com/science/hn/Concern/Athletic_Performance.htm ,diabetes, and aging are all associated with suppression of immune function.)

Preliminary studies in patients with acute or chronic hepatitissuggest that supplementation with Thymomodulin may be helpful.(12,13)However, additional studies are needed to confirm these findings.

In a preliminary study in patients with early HIV infection, Thymomodulinimproved several measures of immune function, including an increase in thenumber of T-helper cells, one of the goals in the treatment of HIVinfection.(14) Thymomodulin (given orally or by injection) has been usedin cancer patients to counteract the decline in white-blood-celllevels that can result from chemotherapy or radiation.(15,16,17,18,19,20) Intest tube studies, Thymomodulin and other thymus extracts have been shown toexert a number of effects on white blood cells (e.g., increasing boththe bone marrow production and functional activity of white blood cells).(21,22)However, it is not yet known if this effect can be achieved with the use oforal thymus extracts.

The oral administration of Thymomodulin has been shown in preliminary anddouble-blind clinical trials to improve the symptoms and course of hayfever, allergic rhinitis http://www.vitacost.com/science/hn/Concern/Sinus_Congestion.htm , asthma,eczema http://www.vitacost.com/science/hn/Concern/Eczema.htm ,and food allergies (in conjunction with an allergy eliminationdiet).(23,24,25,26,27,28,29,30) Presumably, this clinical improvementresults from restoring proper control over immune function.

Thymomodulin given by injection has also been shown to be helpful in the treatmentof diseases of the heart muscle (idiopathic myocarditis and idiopathicdilated cardiomyopathy http://www.vitacost.com/science/hn/Concern/Cardiomyopathy.htm ).(31,32)It is not known whether oral thymus extracts can achieve these samebenefits.

# Where are they found?

Thymus extracts (from bovine sources) are found in capsules and tablets as adietary supplement. Thymomodulin is not available in the United States, andit is unknown whether any of the thymus extracts that are available have thesame effects as Thymomodulin.

# Who is likely to be deficient?

Since it is not an essential nutrient, no deficiency state exists.

# Are there any side effects or interactions?

No side effects or adverse reactions have been reported with the useof thymus preparations.

# Are there any drug interactions?

Certain medicines may interact with thymus extracts. Refer to druginteractions http://www.vitacost.com/science/hn/Supp_Drugix/Thymus_Extracts.htm for a list of those medicines.

# References

1. Cazzola P, Mazzanti P, Bossi G. In vivo modulating effect of a calfthymus acid lysate on human T lymphocyte subsets and CD4+/CD8+ ratio in thecourse of different diseases. Curr Ther Res 1987;42:1011-7.
2. Kouttab NM, Prada M, Cazzola P. Thymomodulin: Biological properties andclinical applications. Med Oncol Tumor Pharmacother 1989;6:5-9 [review].
3. Fiocchi A, Borella E, Riva E, et al. A double-blind clinical trial forthe evaluation of the therapeutic effectiveness of a calf thymus derivative(Thymomodulin) in children with recurrent respiratory infections. Thymus1986;8:831-9.
4. Galli L, de Martino M, Azzari C, et al. Preventive effect of thymomodulinin recurrent respiratory infections in children. Pediatr Med Chir1990;12:229-32.
5. Vettori G, Lazzaro A, Mazzanti P, Cazzola P. Prevention of recurrentrespiratory infections in adults. Minerva Med 1987;78:1281-9.
6. Longo F, Lepore L, Agosti E, Panizon F. Evaluation of the effectivenessof thymomodulin in children with recurrent respiratory infections. PediatrMed Chir 1988;10:603-7.
7. Maiorano V, Chianese R, Fumarulo R, et al. Thymomodulin increases thedepressed production of superoxide anion by alveolar macrophages in patientswith chronic bronchitis. Int J Tissue React 1989;11:21-5.
8. Garagiola U, Buzzetti M, Cardella E. Immunological patterns duringregular intensive training in athletes: quantification and evaluation of apreventive pharmacological approach. J Int Med Res 1995;23:85-95.
9. Wysocki J, Wierusz-Wysocka B, Wykretowicz A, Wysocki H. The influence ofthymus extracts on the chemotaxis of polymorphonuclear neutrophils (PMN)from patients with insulin-dependent diabetes mellitus (IDD). Thymus1992;20:63-7.
10. Calsini P, Mocchegiani E, Fabris N. The pharmacodynamics of thymomodulinin elderly humans. Drugs Exp Clin Res 1985;11:671-4.
11. Braga PC, Dal Sasso M, Maci S, et al. Restoration of polymorphonuclearleukocyte function in elderly subjects by thymomodulin. J Chemother1994;6:354-9.
12. Galli M, Crocchiolo P, Negri C, et al. Attempt to treat acute type Bhepatitis with an orally administered thymic extract (Thymomodulin):preliminary results. Drugs Expt Clin Res 1985;11:665-9.
13. Bortolotti F, Cadrobbi P, Criverllaro C, et al. Effect of an orallyadministered thymic derivative, Thymodulin, in chronic type B hepatitis inchildren. Curr Ther Res 1988;43:67-72.
14. Valesini G, Barnaba V, Benvenuto R, et al. A calf thymus lysate improvesclinical symptoms and T-cell defects in the early stages of HIV infection:second report. Eur J Cancer Clin Oncol 1987;23:1915-9.
15. Kouttab NM, Prada M, Cazzola P. Thymomodulin: biological properties andclinical applications. Med Oncol Tumor Pharmacother 1989;6:5-9 [review].
16. Kang SD, Lee BH, Yang JH, Lee CY. The effects of calf-thymus extract onrecovery of bone marrow function in anticancer chemotherapy. New Med J1985;28:11-5.
17. Schulof RS. Thymic peptide hormones: basic properties and clinicalapplications in cancer. Crit Rev in Oncol Hematol 1985;3:309-76 [review].
18. Meneses G, Delgado MA, Perez-Machado A, et al. Thymostimulin increasesnatural cytotoxic activity in patients with breast cancer. Int JImmunopharmacol 1997;19:187-93.
19. Skotnicki AB. Thymic hormones and lymphokines. Drug Today 1989;25:337-62[review].
20. Ernst E. Thymus therapy for cancer? A criteria-based, systematic review.Eur J Cancer 1997;33:531-5 [review].
21. Vasilopoulos G, Porwit A, Lauren L, et al. The effect of a calf thymusacid lysate on bone marrow cell growth in vitro. ImmunopharmacolImmunotoxicol 1988;10:523-36.
22. Skotnicki AB. Thymic hormones and lymphokines. Drug Today 1989;25:337-62[review].
23. Cazzola P, Mazzanti P, Bossi G. In vivo modulating effect of a calfthymus acid lysate on human T lymphocyte subsets and CD4+/CD8+ ratio in thecourse of different diseases. Curr Ther Res 1987;42:1011-7.
24. Kouttab NM, Prada M, Cazzola P. Thymomodulin: biological properties andclinical applications. Med Oncol Tumor Pharmacother 1989;6:5-9 [review].
25. Marzari R, Mazzanti P, Cazzola P, Pirodda E. Perennial allergicrhinitis: prevention of the acute episodes with Thymomodulin. Minerva Med1987;78:1675-81.
26. Genova R, Guerra A. A thymus extract (thymomodulin) in the prevention ofchildhood asthma. Pediatr Med Chir 1983;5:395-402.
27. Bagnato A, Brovedani P, Comina P, et al. Long-term treatment withthymomodulin reduces airway hyperresponsiveness to methacholine. Ann Allergy1989;62:425-8.
28. Fiocchi A, Grasso U, Travaglini P, et al. A double blind clinical trialson the effectiveness of a thymic derivative (Thymomodulin) in the treatmentof children with atopic dermatitis. Int J Immunother 1987;3:279-84.
29. Cavagni G, Piscopo E, Rigoli E, et al. Food allergy in children: anattempt to improve the effects of the elimination diet with animmunomodulating agent (thymomodulin). A double-blind clinical trial.Immunopharmacol Immunotoxicol 1989;11:131-42.
30. Genova R, Guerra A. Thymomodulin in management of food allergy inchildren. Int J Tissue React 1986;8:239-42.
31. Miric M, Vasiljevic J, Bojic M, et al. Long-term follow up of patientswith dilated heart muscle disease treated with human leucocytic interferonalpha or thymic hormones initial results. Heart 1996;75:596-601.
32. Miric M, Miskovic A, Brkic S, et al. Long-term follow-up of patientswith myocarditis and idiopathic dilated cardiomyopathy afterimmunomodulatory therapy. Immunol Med Microbiol 1994;10:65-74.

## Hepatitis B and Vitamin E http://www.luminet.net/~wenonah/new/howfindv.htm

Associated Press http://www.apme.com/

CHICAGO – Moderate supplements of vitamin E, already believed toprotect older people from heart disease and dementia, also boost the immunesystem in people over 65, a new study found.

The research suggests that older people ought to take about 20 timesmore vitamin E a day than the current recommended daily allowance of 8to 10 milligrams, authors said.

“We looked at three different levels of vitamin E – 60, 200 and 1300milligrams, and the 200 milligrams ( 400 I.U. ) seemed to be optimal,“said immunologist Simin N. Meydani of the USDA Human Nutiition ResearchCenter on Aging at Tufts University in Boston.

The researchers compared supplements with a placebo among 88 healthy peopleage 65 and older. They reported the results in Wednesday’s issue of theJournal of the American Medical Association.

Daily 200-milligram supplements for four months increased subjects’T-cell function by 65 percent and their response to hepatitis B vaccinesix fold, compared with placebos, researchers said.

T-cells are white blood cells that help fight viruses and tumors andcontribute to the body’s defenses in other ways. Vaccine response refers tothe level of protection that a vaccine provokes in the body.

No adverse effects were reported. Doses of 800 milligrams boostedimmunity similarly in those measures and others, but pushed them no higher,Meydani said.

## Urea to cure Hepatitis http://www.luminet.net/~wenonah/new/nieper.htm

Even urea in the amount of 7-15 grams daily has obviously spectaculareffects on certain forms of cancer – especially advanced cancer ofthe liver. Although in 1974 Dr. Danopuolos, Professor at the GreekCancer Clinic discussed this in detail in the British magazine “Lancet”this path was not further pursued by orthodox medicine. This therapy is veryinexpensive, mostly harmless and can be administered for a prolongedperiod. The underlying principle seems to be an antiviral effect.The effect of the urea therapy is limited to cancers, which are known to bestarted by the foregoing viral infections. This is true for livercancers (hepatitis B) and for oral tumors (herpes virus).

A further method to detoxify the cancer cells from the inside consists ofthe introduction of L-glutathione, a compound with sulfureous amino acids.Known results up to now permit prediction of benefits from this treatment.

… Insects and sharks are phylogenetically extremely old. Their ability toconserve and safeguard their gene system is just superb. Gene repairincluding anti-cancer and anti-viral is likewise very old and Primitive,much older than our sophisticated and delicate immune systems which areconstantly brought to the doctor for possible servicing.

In Germany a very strange custom has prevailed for many decades, andI have seen very many reasonable people swearing by it. It is the eatingof certain lice, which normally live on sheep, for the cure ofviral hepatitis. Although I have always kept an open mind withrespect to unconventional medicine, I had always classified the sheep licecure as “spooky.” Now, with the discovery of the iridoides, eventhis cure may look different.

It is certainly reasonable to assume that the U.S. Food and DrugAdministration, and orthodox medicine, do not have in mind to officiallyapprove the sheep lice cure.

… Meanwhile the strong suspicion has arisen that in many other organ tumors,viruses – especially of the herpes group, as well as those of hepatitis-Band the so-called cytomegaloviruses – are more or lessco-responsible for the initiation of the malignant process, i.e., for thereal cancer genesis in the cell. This suspicion applies to the followingtumors: ovaries;*

[ * Approximately in 1960, a Munich gynecologist Dr. Philippine Hartmann,made an extraordinary discovery: If a cell-free extract of a human ovariancancer is applied to the egg membrane of a chicken egg, so-calledcytopathogenic defects occur, i.e., the beginnings of cancerous development.Thus, the human ovarial cancer must contain a perhaps virus-like cancerexcitant. While Dr. Hartmann reported on her findings to the world cancercongress in Houston, Texas, in 1970, she was so excited that she lost hervoice and could not be understood. Perhaps she had been utterly speechlessbefore the conference because of attitudes of the orthodox Munich cancerclinicians, who, after all, had also been instrumental in the lawsuitagainst Dr. Issels! ]

bladder; kidneys; prostate; all tumors in the nose, mouth and throat area;certain tumors of the so-called adenocarcinoma type, of the windpipe and thebronchia in the lungs; lymphomas; the so-called clear cell melanomas;melanomas in general; and pancreas, which was repeatedly observed followingacute shingles. It also applies to primary liver cancer after earlier viralhepatitis-B. Furthermore, apparently viruses of the herpes group alsoplay a role in Hodgkin’s Disease (lymphogranulomatosis). However, the lattermust be included among the immune diseases, which can also lead to – amongother things – the development of equally malignant primary tumors atseveral locations.

Finally, there are several originally tropical tumors, such as the so-calledBurkitt lymphoma, caused by Epstein-Barr viruses, which belong to the herpesgroup.

…In this context, a further comment will be of great interest. On January26, 1974, the Greek oncologist, Professor Danopoulos, published somevery interesting observations in the British technical journal “The Lancet.”Large primary cancer of the liver had undergone remission in severalpatients following a very simple therapy. The patients received 10-18grams of urea daily. This is a very inexpensive product. One observedside effect was that the flow of urine was strongly stimulated,since the urea had to be eliminated again. This increased urine flow alsodetoxifies the body of cancer degradation products. It has also been knownfor some time, that urea can treat herpes virus infections andhepatitis-B virus infections. And these are precisely the possiblecancer-generating viruses. Since, as a rule, at least, in animalexperiments, urea has hardly any healing effect on cancerous tumors, itseffect in these special clinical cases apparently depends on its ability toinactivate the virus genome in the cancer cell. We found, in any event, thaturea is effective on liver tumors, and especially on the oftenhard-to-treat tumors in the mouth, nose and throat region.

We must derive yet another piece of information from this observation. Itseems obvious that the cancer cell is not quite as autonomous as has beenassumed so far. The inactivation of its original starter or generatorapparently also threatens its own autonomy. At the 1982 cancer congress inBaden-Baden, another interesting discussion took place, in this context. TheItalian researcher Dr. Anna Novi described how liver cancers generated byaflatoxin had been regressed by means of the sulphur-containing peptideglutathion. it was seriously argued that glutathion might be active not somuch against the cancer cell itself, as against the aflatoxin, its originalstarter. Aflatoxin is a strongly carcinogenic substance which is secreted bycertain fungi, which themselves thrive on peanuts.

## Hepatitis B Virus (HBV) Overview from http://www.hon.ch/Hepatitis/HBV_Complement.html

9.3 – Complementary Medicine

To my knowledge there is no proven cure for hepatitis B in this areaof medicine, this is not to say there is no cure in these areas. The problemis there is very little research being done and controlled studies areuncommon. Where a person has been “cured” due to the lack of doubleblind studies with reasonable to large groups of people it is difficult tosay if it would have happened anyway as occurs in between 2%-5% of peopleeach year or due to the complementary medicine.

However there are treatments available where it is believed that damagedue to hepatitis may be limited, cause relief of symptoms, help withinterferon side effects etc

A note of caution, some herbs and minerals given to people can have beenfound to cause liver damage and some herbs increase liver enzymes and somask the results of conventional treatment/ongoing disease. Some in only ina small percentage of people, some in all and some may be dosage dependent,I therefore advise you to research any herbs and minerals you decide to takeand discuss them with your medical practitioner and make an informeddecision.

This is a large topic and information is taken from various sources.Unfortunately the scientific rigour of controlled studies, double blindtrials and confirmation of results rarely occurs with complementary therapyand some times outrageous claims are made. Similarly often usefultreatments are ignored by conventional medicine. So please treat theinformation here as a pointer to your own research. Also the length of theinformation does not signify the value of it!

I hope to expand this section further in future versions however variousherbs, vitamins, amino acids etc you may wish to research are:- MilkThistle (Silymarin); Aloe Vera; Thymic Factors, Mega doses of Vitamin C;Melatonin; Methinonine (An amino acid), Acytyl-L-Cystine, Choline, Ginseng(Note: This may have a mild imunosupressive effect through glycocortisoidaction and is therefore not advised if taking interferon, although a coursebefore starting on interferon may have a slight priming effect for theimmune system and be beneficial(?) ); Goldenseal; licorice root; GotuKola; details of some of these are shown below:-

# Artichoke (CYNARA SCOLYMUS, Cynarin, CAFFEIC ACID )

An excerpt from the following article: SILYMARIN COMPLEX FOR LIVERDISORDERS by Michael T. Murray, N.D. published in “Health World“spring 1987.

The artichoke has a long folk history in treating many liver diseases.Recent evidence supports this long-time use. The active ingredient inartichoke is cynarin. this compound is found in highestconcentrations in the leaves.

Like silymarin, cynara extract has also demonstrated significant liver-protectingand regenerating effects. it also possesses choloeretic effect,promoting the outflow of bile from the liver to the gall-bladder. This is avery important property. If the bile is not being transported adequately tothe gallbladder, the liver has an increased risk of being damaged.Choleretics are very useful in the treatment of hepatitis andother liver diseases via this “decongesting” effect.

Choleretics typically lower cholesterol levels via their ability todecrease the synthesis of cholesterol in the liver. Consistent withits choleretic effect, cynara extract has been shown to lower bloodcholesterol and triglyceride levels in both human and animal studies.

CLINICAL TRIALS OF CYNARA SCOLYMUS
In a controlled trial, two groups of 30 patients having elevated serumcholesterol and triglycerides were given either cynarin (500 mg. perday) or a placebo. Cynarin proved to induce a significantreduction of these elevated cholesterol and triglyceride levels.
In addition, the patients also displayed a reduction in body weight.This effect was probably a result of cynarin’s diuretic activity.

CAFFEIC ACID
It appears cynarin, the active component in artichoke leaves extracts,is not the true active substance. Since cynarin can be broken downinto caffeic acid in the gastrointestinal tract, it isconceivable that the true active component is caffeic acid. This compoundhas demonstrated a significant liver-protecting effect as well ascholoeretic activity.
Cynara Extract has also demonstrated significant liver-protecting andregenerating effects.

# Liquorice root

– From the “Encyclopaedia of Natural Medicine”, Michael Murray, N.D.and Joseph Pizzorno, N.D.

The recommended dosage of Liquorice (Glycyrrhiza glabra) for hepatitisof all kinds is:

(Doses 3 times per day):
Dried root (or as tea, 1 to 2 g.
Tincture (1:5), 4-6ml (1 to 1.5 tsp)
Fluid extract (1:1), 0.5-2.0 ml (1/4 to 1/2 tsp)
Powdered solid extract (4:1), 250-500 mg

If liquorice is used over a long time it is necessary to increase theintake of potassium rich foods.

Double-blind studies have shown a liquorice component to be effective intreating viral hepatitis, particularly chronic active hepatitis. Thisactivity is probably due to its well documented antiviral activity. Aglycyrrhizin-containing product (Stronger Neo-minophagen C),consisting of 0.2 per cent glycyrrhizin, 0.1 per cent cysteine and 2.0 percent glycine in physiological saline solution, is widely usedintravenously in Japan for the treatment of hepatitis. The othercomponents, glycine and cysteine, appear to modulate glycyrrhizin’sactions. Glycine has been shown to prevent the sodium- andwater-retaining effects of glycyrrhizin, while cysteine aids indetoxification via increased glutathione synthesis and cystine conjugation.

Licorice as a liver herb by Paul Bergner

Licorice root (Glycyrrhiza glabra) is a time-honoured herbal medicine inall world herbal traditions. It is used as a primary herb in perhapsmore categories than any other medicinal plant. It is used with success foracute respiratory problems, gastric ulcers, gastritis, inflammatoryconditions in general, and adrenal exhaustion. Components of licoriceroot have both estrogenic and anti-estrogenic activity (Leung;Kraus; Kumagai et al; Sharaf and Goma; Tamaya et al). It is thus animportant herb for treating hormone-related female problems. It has not traditionallybeen used as a liver herb, but medical research over the past twodecades in Japan and China has shown that licorice is also an importantliver herb with strong hepatoprotectant properties. This should not bethought of as just another minor use for licorice. It is as significant ahepatoprotectant as the better-known milk thistle seed, and acts throughseparate mechanisms than that herb.

The two together should be considered in any hepatoprotecant formula ortreatment plan. Form and dose Most of the Asian clinical research andpractice has been with glycyrrhizin, a major constituent of licorice root.The product in most Japanese trials is Strong Neominophagen-C (SNMC)which contains 40 mg glyzyhhrizin, 20 mg cysteine, and 400 mg glycine in20 ml saline solution. Cysteine and glycine are amino acids. Atypical treatment for hepatitis is 40 ml of SNMC a day for thirtydays delivering 80 mg of glycyrrhizin per day (Hikino). Theupper range of clinical trials has been 200 ml SNMC (400 mg glycyrrhizin)(Mori et al, 1989, 1990), but trials above 100 ml (200 mg glycyrrhizin) havebeen rare, due to concern over possible side effects (see below) (Hikino).

Oral extracts Comparable therapeutic levels of glycyrrhizin canprobably be reached with oral preparation; important active constituent oflicorice, and therapeutic levels for a wide variety of conditions are easilyachieved with oral administration. Licorice root (G. glabra) contains 6-14%glycyrrhizin ( erck), so an oral dose of 7-8 grams powdered licoricewould deliver it.

HEPATITIS

Clinical trials for hepatitis, especially chronic active hepatitis,have been so successful in Japan that glycyrrhizin is now a standardmedical treatment there (Kumada et al; Matsunami et al.; Ohta etal; Su et al; Suzuki et al; Wang; Zhang et al).

MECHANISMS OF HEPATOPROTECTION

The mechanisms of hepatoprotection are diverse, and include antioxidantactivity (Kiso et al; Abdugafurova et al; Tan; Ju et al), direct antiviraleffects (Hikino; Crance), enhancement of interferon production (Hikino;Shinada); enhanced antibody production (Hikino), enhancement ofextrathymic T-Cell activity in the liver (Kimura et al), andprotection from immunological (auto-immune) injuries (Hikino; Mizoguchi etal). A number of animal and in vitro trials have shown that glycyrrhizin canprotect liver cells from damage from a variety of chemical or immunologicalagents (Nakamura et al; Mizoguchi et al; Shibayama; Shiki et al; Zhao etal).

OTHER CLINICAL TRIALS

Glycyrrhiza has also been effective in treating HIV/ARC in haemophiliacs,and, notably, improved liver dysfunction in these patients (Mori et al,1990; Mori et al, 1989). It has also been effective in preventing thehepatic side effects of chemotherapy with a methotrexate combinationor interferon (Akimoto et al; Hayashi et al), and in treating generalhepatic failure (Acharya).

ENTEROHEPATIC CYCLING

One reason licorice is so effective in treatment of the liver is that itenters the enterohepatic loop, that is, it is excreted in the bile,then reabsorbed in the gut to recycle repeatedly through the liver(Ichikawa; Ishida).

SIDE EFFECTS AND DRUG INTERACTIONS

Licorice produces well-documented side effects when taken in large doses(>>50 g/day) or for long duration (>>six weeks) (Wichtl).No such side effects have been observed in clinical trials of 40 ml SNMC/dayfor thirty days, or with 100 ml SNMC (200 mg glycyrrhizin/day) ~for a shortperiod~ (Hikino). With widespread use of SNMC in japan, hyperaldosteronismwas seen with larger doses and extended use (SNMC). The side effect isreversible on discontinuation of glycyrrhizin. Licorice or glycyrrhizin mayalso interact with herbs or other medications containing cardiac glycosides.

# Milk Thistle (Silymarin, blessed thistle, Chardon Marie)

Milk Thistle (Silymarin) is reported to be an anti-inflammatory and mastcell stabilizer that helps protect the liver against toxin, drugs, andthe affects of alcohol (Better Nutrition for Today’s Living, March 1993).I .Two capsules of 100mg extract of milk thistle (Silybum marianum)containg 70% sillymarin (ie 140mg of silymarin) are normally taken so twiceor three times a day. European research shows that it stimulatesregeneration of liver cells and protects them from toxic injury” It isusually stocked in health food stores under the names milk thistle,silybum, or silymarin.

In germany milk thistle is frequently prescribed to those on interferon.

From the Encyclopedia of Natural Medicine Michael Murray, N.D. andJoseph Pizzorno, N.D. :

The common milk thistle contains some of the most potent liver protectivesubstances known, a mixture of three flavanolignins colelctivelyreferred to as silymarin. (30-33) The concentration of silymarin is highestin the fruit, but it is also found in the seeds and leaves.

Silymarin’s effect in preventing liver destruction and enhancing liverfunction relates largely to its ability to inhibit the factorsthat are responsible for hepatic damage, i.e., free radicals andleukotrienes, coupled with an ability to stimulate liver protein synthesis.(30-33)

Silymarin prevents free radical damage by acting as an antioxidant.

Silymarin is many times more potent in antioxidant activity than vitaminE. Silymarin not only prevents the depletion of glutathione (GSH)induced by alcohol and other liver toxins, but it was shown to increasethe basal GSH of the liver by 35 per cent over controls in one study.This is extremely useful when exposure to toxic substances is high, due toglutathione’s vital role in detoxification reactions.

The protective effect of silymarin against liver damage has beendemonstrated in a number of experimental and clinical studies. (30-38)Experimental liver damage in animals can be produced by such diverse toxicchemicals as carbon tetrachloride, amanita toxin, galactosamine andpraseodymium nitrate. Silymarin has been shown to protect against liverdamage by all of these agents. (30-33)

Another way in which the liver can be damaged is by the action ofleukotrienes. These compounds are produced by the transfer of oxygen toa polyunsaturated fatty acid. This reaction is catalysed by theenzume lipoxygenase. Silybum components inhibit this enzyme, thereby inhibitingthe formation of these damaging compounds.

Perhaps the most interesting effect of silybum components on the liver istheir ability to stimulate protein synthesis. (30-33) The result isan increase in the production of new liver cells to replace the damaged oldones. This demonstrates that silymarin exerts both a protective andrestorative effect on the liver.

In human studies, silymarin has been shown to have positive effects intreating liver diseases of various kinds, including cirrhosis, chronichepatitis, fatty infiltration of the liver (chemical and alcohol inducedfatty liver) and inflammation of the bile duct. (32-38) The therapeuticeffect of silymarin in all of these disorders has been confirmed byhistological (biopsy), clinical and laboratory data. Silymarin is especiallyeffective in the treatment and prevention of toxic chemical or alcoholinduced liver damage. (32-38)

REFERENCES:

30. Hikino, H. Kiso, Y., Wagner, H. and Fiegig, M., “Antihepatotoxic actionsof flavonolignans from Silybum marianum fruits”, Planta Medica, 1984, 50, pp248-50
31. Vogel, G., Trost, W., Braatz, R., et al., “Studies on pharmacodynamics,site and mechanism of action of silymarin the antihpatotoxic principle fromSilybum marianum (L.) Gaert”., Arzneim-Forsch, 1975, 25, pp 179-85
32. Wagner, H., Antihepatotoxic flavonoids”, in Cody, V., Middleton, E. andHarbourne, J.D. (eds), Plant flavinoids in Biology and Medicine:Biochemical, Pharmacological and Structure-Activity relationships, Alan R.Liss, New York, NY 1986, pp545-58
33. Wagner, H., “Plant constituents with antihepatotoxic activity”, in Beal,J.L. and Reinhard, E. (eds) Natural Products as Medicinal Agents,Hippokrates-Verlang, Stuttgart, 1981
34. Sarre, H., “Experience in the treatment of chronic hepatopathies withsilymarin”, Arzneim-Forsch, 1971, 21, pp 1,209-12
35. Canini, F., Bartolucci, A., Cristallini, E., et al., “Use of silymarinin the treatment of alcoholic hepatic stenosis”, Clin. Ther., 1985, 114, pp307-14
36. Salmi, H.A., and Sarna, S., “Effect of silymarin on chemical,functional, and morphological alteration of the liver. A double-blindcontrolled study” Scand.J.Gastroenterol., 1982, 17, pp 417-21
37. Scheiber, V., and Wohlzogen, F.X., “Analysis of a certain type of 2 x 3tables, exemplified by biopsy findings in a controlled clinical trial”,Int.J.Clin.Pharmacol., 1978, 16, pp 533-5
38. Boari, C., Montanari, M., Galleti, G.P., et al., “Occupational toxicliver diseases. Therapeutic effects of silymarin”, Min.Med., 1985, 72, pp2,679-88.

# Some Modern Uses of Milk Thistle Seed by Paul Bergner

Milk thistle seed extracts, usually standardized to 70% silymarincontent, are commonly used in conventional medicine in Europe, whereit has been officially available since 1969. More than $180 millionin silymarin products were sold in Germany alone in one recent year. Thetrials below all used this 70%-silymarin pharmacetuical preparation, butthis does not in any way prove that only such preparations would have thisclinical result. See the accompanying articles for reports of clinical useof other forms of milk thistle seed.

HEPATITUS

In 77 patients with acute viral hepatitis, 42 were treated withplacebo and 35 with a milk thistle seed extract. Recovery time for theplacebo group averaged 43 days, and for the silymarin group, 29 days(Legalon).

ALCOHOLIC CIRRHOSIS

In a well-controlled double-blind study of ninety-six cases of alcholichepatic cirrhosis, forty-nine patients were treated with placebo andforty-seven with silymarin. After a five-year period, there were onlyfive deaths (10.5%) in the silymarin group, and fourteen deaths(28.5%) in the control group (Benda et al).

PEDIATRIC LIVER DISEASE

In a study of 166 children under the age of seventeen with chronic liverdisease, the following results were obtained: For cases of chronicpersistent hepatitis, 70% showed improvement, 27% stabilized; 4% hadno improvement or stabilization. For cases of chronic active hepatitis, 32%showed improvement; 44% stabilized, and 24% had no beneficial effect(Jodl et al).

FATTY DEGENERATION

In a group of 88 patients with toxic-metabolic liver damage due toalcohol abuse or diabetes mellitus, elevated transmaminase valuesand abnormal bromsulphalein test results tended to revert to normal.Ninety-one abnormal test results fell to only 37 (59% improvement) aftertreatment with silymarin (Fintelman V).

PHARMACEUTICAL DRUGS

In a study of sixty-six female patients taking spychopharmacological oranticonvulsant agents for neurological or psychiatric problems, liverfunction tests gave a total of 71 abnormal results. Fifty-two of these (73%responded to silymarin treatment, the gret majority of them returning tonormal ranges (Legalon).

ANESTHESIA

In sixty-one patients receiving anesthesia using halothane or hexobaribtal,the thrity-two control showed a distinct post-operative rise in serumenzymes. Twenty-nine patients receiving silymarin showed no such rise (Bendaand Zenz).

OCCUPATIONAL TOXINS

Studies showed that silymarin could rapidly cure workers producingpesticides who had disturbed liver function; other studies showed thatin forty patients with posioning by silicon dioxide, the effect could becompletely antagonized by silymarin at certain doses (Legalon)

Phylanthus Amarus/Nituri/Nirruri (the Ayurvedic name is Bhumy Amalaki)

Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus.Lancet. 2(8614):764-6, 1988 Oct 1.

“Abstract: In a preliminary study, carriers of hepatitis B virus weretreated with a preparation of the plant Phyllanthus amarus for 30days. 22 of 37 (59%) treated patients had lost hepatitis B surfaceantigen when tested 15-20 days after the end of the treatment comparedwith only 1 of 23 (4%) placebo-treated controls.

Some subjects have been followed for up to 9 months. In no case has thesurface antigen returned. Clinical observation revealed few or notoxic effects. The encouraging results of this preliminary study recommendcontinued evaluation of this plant and the active principles isolated fromit.”

Please note the small numbers of patients and the emphasis that this is apreliminary study. A medline search shows that many researchers have failedto confirm these findings, while others show prominsing, usually in vitro,results.

# Thymus Extracts

Excerpts from Dr. Julian Whitaker’s “Health and Healing” monthlynewsletter. Oct. 1992, Vol. 2. No. 11. The “proofs” offered re: oralthymus supplements are mostly anecdotal.

The thymus gland controls your immune system in to basic ways. First it isthe source of T-lymphocytes or T-cells (T stands for thymus), which arecrucial in the fight against viruses, bacteria, yeast, and all other foreigninvaders. Early in life the thymus gland seeds the bone marrow with immatureT-cells, where they multiply and mature. It is the T-cells that aredestroyed by the HIV virus and their destruction brings on full-blown AIDS.

Second, the thymus gland produces a variety of hormones that stimulate thematuration of T-cells and increase the production of other immune hormones,such as interferon and the immune globulins. Several hormones from thethymus gland have been isolated, but the one receiving the most attentionright now is thymosin alpha 1.

Researchers all over the world are exploring the therapeuticpossibilities of thymus hormone replacement, but none are morevigorously than Milton Mutchnick, MD, head of the department ofgastroenterology at Hutzel Hospital and associate professor ofmedicine at Wayne State University medical Center in Detroit. Herecently published a year-long study demonstrating that a syntheticinjectable version of a thymus hormone, thymosin alpha 1, giventwice weekly, eliminated the hepatitis B virus in six out of sevenpations (86%), compared to a spontaneous conversion of one outof five (20%) in the placebo group.

EUROPEAN STUDIES SHOW VALUE OF THYMUS EXTRACT

Oral products of thymus extract are shunned in this country becausemost researchers believe that the digestive juices in the stomach andintestines will destroy them before they are absorbed. However, inEurope, an oral thymus product, Thymodulin, with sales of over $300million a year, has been sued and studied for almost a decade. Controltrials show that it significantly improves a variety of conditions andeven eliminated hepatitis b in 45% to 50% of children, compared toonly 20% in the control group.

In one convincing study, oral Thymodulin was administerd to 29 patients:eight with herpes zoster, eight with whooping cough, eight with chicken poxand five with infectious mononucleosis.

Another 29 patients with the same diseases received a placebo.

Various parameters were used to measure the effectiveness of Thymodulin, andall patients who received it showed significant improvement compared tocontrols.

Dr. Burgstiner (Savannah GA) contracted Dr. Mutchnick, whowas very interested in Dr. Burgstiner’s experience and wanted to have a lookat the product he had used. Dr. Mutchnick took Immunoplex 402 and thevitamin preparation himself, and then measured his blood levels ofthymosin alpha 1. He wrote Dr. Burgstiner: “You might be pleased to knowthat I conductd a pilot study on myself by taking several of the Immunoplex402 tablets after having first obtained a pretreatment serum, which wasfollowed then by serums at 1/2 hour, 1 hour, 2 hours, 3 hours, and 4 hours.Lo an behold, by the first hour–and consistently for the next severalhours– the thymosin alpha 1 level, as determined by the ELISA,increased. Clearly, I will have to repeat this on a number ofsubjects, but this offers an exciting potential for turning thymosinalpha 1 from a subcutaneous injection into an oral preparation.”

Dr. Burgstiner encouraged Melvin L. Haysman, MD, who practices allergyand clinial immunology in Savannah, to try the products with some ofhis patients. Dr. Haysman collected before and after blood smaples of abouta dozen patients who took Immunoplex 402 with the vitamins and minerals, andsent them to Dr. Mutchnick.

Dr. Mutchnick found that the products had increased the blood levels ofthymosin alpha 1 in every patient, and in some by 300% to 700%.

WHY NUTRITIONAL SUPPLEMENTS SHOULD BE ADDED

Vitamin and mineral supplements taken with the Immunoplex 402 markedlyenhance the effect of the product. Dr. Mutchnick found that threeImmunoplex 402 tablets taken with one vitamin and mineral supplementelevated the blood level by over 300%, and three Immunoplex 402 tablets plustwo of teh vitamin and mineral supplements caused an almost 450% rise inthymosin alpha 1 hormone.

It should not be a surprise that supplemental nutrients would have thiseffect on the oral preparation. In one recent study from italy, zincsulfate was added to the serum of patients with Down’s syndrome (knownto have very low levels of thymus activity) and of elderly patients, alsowith characteristically low levels of active thymus hormone. The activehormone in their serum icnreased to that of young, healthy individuals.

The authors theorized that zinc is necessary to activate thymus hormone,and that marginal zinc deficiences could be a cause of immune dysfunctionand decreased function of thymus hormone even when it was present. The sameis likely true for other essential nutrients as well. One of the first andmost consistent signs of any nutrient dificiency is immune dysfunction. Butvery few doctors prescribe nutritional supplements. They all “know” theydon’t work. And blah blah blah….

THE POTENTIAL FOR PREVENTING AGE-RELATED DISORDERS

The ability to maintain high levels of thymus hormone activity hasenourmous petential for alleviating suffering from age-related diseases,and the anecdotal experience of Drs. Burgstiner and Haysman is remarkable.Dr. Burgstiner has been keeping a running tally of th benefits reported tohim by patients and doctors of patients who have tried the preparations.This is not a scientific study, but over the last two years…

63 patients have reported complete recovery from Hep B.
3 patients with Hep C recoverd
26 patients with chronic fatigue syndrome reported marked improvement.
24 patients with rheumatoid arthritis — some taking methotrexate,cortisone, and gold shots, indicating very severe conditions — reportedalmost complete remission of symptoms and elimination of strongmedications.

# Tumeric (Curcumin)

An excerpt from the following article: SILYMARIN COMPLEX FOR LIVER DISORDERSby Michael T. Murray, N.D. published in “Health World” spring 1987

Curcumin is the yellow pigment of tumeric. Curcumin shares someof the same effects on the liver as silymarin and cynarin. It hasdemonstrated similar liver protection activity to silymarin.Curcumin is believed to also be converted to a choleretic compound, perhapseven caffeic acid. Curcumin’s documented choleretic effects support its historicaluse in treating liver and gallbladder disorders. Like cynara extracts,curcumin has also been shown to lower cholesterol levels.

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## ASCORBATE AND THE POSSIBLE PREVENTION OF AIDS, http://www.orthomed.com/aids.htm

Morishige has demonstrated the effectiveness of ascorbate inpreventing hepatitis B from blood transfusions (20). Asimilarity exists between AIDS and hepatitis B. It has been my experiencethat patients treated with large doses of ascorbate during the acutephase of hepatitis will not develop chronic hepatitis. My experiencewith herpes simplex has been the same. Although ascorbate is helpful to adegree with chronic viral infections, it is in the treatment of acute viraldiseases that it is most effective.

It is on this basis that I recommend that all persons who fear exposure toAIDS and certainly anyone receiving blood trans- fusions or other bloodproducts which could in the most remote way have been obtained from an AIDScarrier, be put on bowel tolerance doses of ascorbate.

## Live Protein Therapy in the Management of Liver Disease,by Thomas Bayne, DC. from http://www.tldp.com/issue/11_00/protein.htm

Liver disease is the third leading disease-related cause of death forAmericans aged 25-59. Hepatitis and cirrhosis are particularly common liverdisorders that are part of the degenerative cascade of liver diseasethat starts with inflammation and swelling and develops into fattydegeneration, cirrhosis, and cancer.1

Two live protein extracts are regularly employed in treating liverdisease: thymus proteins are used to increase the hosts’ resistance andare responsible for cell-mediated immunity, and liver proteins to improvethe regenerative capabilities of the liver. Researchers have recentlyindicated Hepatocyte Growth Factor (HGF), as one of the manyproteins and growth factors found in the liquid liver extract. Clinicalapplications of HGF represent an exciting new direction in the treatmentof liver disease. This article will define the disorders and discusstreatments using biologically active proteins such as HGF found in liverextract, combined with thymus gland proteins, to modulate immune response,stimulate liver regeneration, accelerate hepatic function, reverse fibrosisand cirrhosis.

Hepatitis is defined as an inflammation of the liver that isassociated with cellular damage or death of the liver cell. There are twoforms of hepatitis: acute hepatitis, which is typically self-limiting,and chronic hepatitis, which may be benign but sometimes develops intoprogressive liver damage often leading to cirrhosis, hepatic failure anddeath.2 Symptoms of hepatitis include extreme fatigue, loss ofappetite, weight loss, fever, nausea, and vomiting. Dark urine typicallyappears within 3-10 days and is followed by a yellowing of the skin, calledjaundice. Jaundice takes 7-10 days to develop and 2-4 weeks to fade away.The liver is usually enlarged and tender to palpation. The most common causeof hepatitis is contamination by virus. The American liverfoundation identifies five different viruses that cause hepatitis: theA, B, C, D and E viruses.

Hepatitis A is usually a benign self-limiting disease thataccounts for 20-25% of the cases of acute hepatitis.2 It does not causechronic hepatitis or a carrier state and so the fatality rate is about0.1%.3

Hepatitis B (HBV) can produce an asymptomatic carrier state, acutehepatitis, chronic hepatitis, progression of chronic disease to cirrhosis,and/or fulminant hepatitis with massive liver necrosis.2 HBV also plays aprominent role in the progression of hepatocellular carcinoma.

Hepatitis C (HCV) is mostly transfusion-associated with as many as60% of acute HCV infections progressing to chronic hepatitis. HCV isresponsible for at least 30% of the cases of fulminant viral hepatitis.4

Hepatitis D only develops when there is concomitant hepatitis Binfection and is relatively uncommon in the United States.2

Hepatitis E (HEV) is responsible for large epidemics of acutehepatitis in Asia, the Middle East, Africa, and Mexico. Chronic hepatitis Einfection has not been observed, accounting for the low death rate due toHEV. However, HEV has a 25% death rate in pregnant females.5

# Allopathic Treatment of Hepatitis

Modern medical treatment consists of interferon alfa-2b, recombinantalone or in combination with Rebavirin. Side effects from thesemedications include muscle aches, yeast infections, anemia, seizures,brain fog, autoimmune reactions, hypersensitivity reactions (allergicreactions, asthma) osteoporosis, deterioration of cardiac function,coronary disease, diabetes mellitus, and severe psychiatric symptoms suchas depression and suicidal behavior. Rebavirin is so dangerous to adeveloping fetus that women of childbearing age must show proof of 2 formsof acceptable birth control before they are given a prescription.

# Holistic Treatment of Hepatitis

Diet

A whole foods diet that is low in protein will minimize stress onthe liver. An elimination of refined flours and sugars, caffeine, andalcohol is crucial. Vegetable broths and juices should be emphasizedwith particular attention to spirulina, chlorella, wheat grass juice, andbarley juice. A minimum of 4 glasses of water for every 50lbs of bodyweight should be consumed daily.

# Live protein therapy

The liver injury in HBV infection is due to an immune mediated hostreaction to the infection and not the infection per se.6 In one HBVstudy, thymus extract was used to modulate immune mediated reactions.Eighteen patients with biopsy-confirmed hepatitis B and lowered T4/T8 ratiowere split into two groups and received thymic extract for 6 and 12 monthsrespectively. There was a normalization of both biochemical andimmunological markers within 6 months of beginning treatment. Laboratorymarkers revealed a complete cessation of viral replication, which impliesremission.7 Two-year follow-up showed continued remission with normalimmunological and biochemical panels. A similar study on a larger patientgroup produced similar findings and conclusions.8

The use of Liver extract and more specifically Hepatocyte GrowthFactor(HGF) has demonstrated the ability to accelerate hepaticfunction.9 One hepatitis study showed that HGF stimulated the regenerationof hepatocytes under inflammatory conditions such as hepatitis B and C.10

Liver extract has also demonstrated remarkable results in the treatmentof chronic hepatitis. A double-blind study was conducted that involved556 patients with chronic hepatitis. One group was given 70mg of liverhydrosylate three times per day and the other group placebo three times perday. At the end of three months of treatment the group receiving the liverextract had far lower liver enzyme levels. Since the levels of the enzymesin the blood reflect damage to the liver, it was concluded that the liverextract is effective in the treatment of hepatitis through its ability toimprove the function of damaged liver cells and to prevent furtherdamage to the liver.11

Cirrhosis is a category of chronic liver disease associated withinterconnecting fibrous scars that eventually lead to parenchymal nodulesthat create further damage and scarring eventually developing arteriovenousinterconnections. Symptoms appear such as mild fatigue, indigestion,constipation or diarrhea and skin rashes. These are followed by abdominalswelling, pain, vomiting of blood and jaundice. Advanced cases lead to comaand eventually death. Researchers recently discovered that the scartissue associated with cirrhosis is not permanent and in fact is actuallyreversible.12 The following protocol has demonstrated the ability toreverse cirrhosis.

# Live Protein Therapy

Radchenko et al. successfully treated 102 patients with chronichepatitis and primary biliary cirrhosis with thymus extracts.The results showed a significant increase in immune competence,which helped control the immunoinflammatory process in the liver andnormalized the clinical manifestation of the disease leading to afavorable outcome.13

HGF has also shown great clinical potential in the treatment of cirrhosis inanimal models. The antiapoptotic activity of HGF in hepatocytes14 is ofparticular interest pertaining to the process of cirrhosis. In addition, HGFwas a potent stimulator of DNA synthesis in primary hepatocytes.9,15 Theseimportant results demonstrate successful treatment of a very difficultdisease that typically has a very unfavorable outcome.

# Hepatitis Case Study

A.L. presented with a history of hepatitis C infection that wascontracted after a blood transfusion in 1980. A liver biopsy in 1996confirmed chronic hepatitis C. The patient’s medical doctor told him that hehad three to five years to live. A.L. was searching for “palliativecare” to “make the last few years of my life as comfortable as possible”when we began therapy. A comprehensive program was implemented that includeddietary modifications combined with live thymus proteins, live liverproteins, and detoxification therapies. Concurrently, asolution-focused psychotherapeutic approach aimed at increasing coping andmanaging emotional fear and distress was implemented.

For the first month of care A.L. took three Natcell Thymus, and oneNatcell Liver per week. After four weeks of care A.L. reported a markedincrease in energy levels, and general improvement in overall well-being.Months two through four A.L. took two Natcell Thymus per week and oneNatcell Liver every two weeks. Over the next six months the dosage wasslowly decreased to one Natcell Thymus every two weeks and one Natcell Liverper month. Reports from his psychotherapist indicated that his mindset waschanging from a hopeless helpless posture to a hopeful and optimisticmindset. At the end of the 10-month period A.L. was given a completeclean bill of health. There was no sign of viral infection in hisbody.

For the next two months a heavy program of Natcell liver combinedwith coffee enemas was introduced to further rebuild and rejuvenatethe liver. In the first month A.L. took two Natcell Liver per week andperformed three coffee enemas per week. The second month consisted of oneNatcell Liver per week and two coffee enemas per week. Twelve months aftertherapy had begun, A.L had gained 20lbs of lean muscle. He has integrated amind-body appreciation for his new health; he has adopted a new philosophyon life and remains healthy to this day. He remains on a maintenancedose of one Natcell Liver every six weeks and one Natcell Thymus every eightweeks.

# Conclusion

Live protein therapy represents a viable treatment option in themanagement of liver disease. Although Organotherapy is by nomeans a new concept, our understanding of the science behind the mechanismof action is beginning to become clearer. Clinically, I have witnessedresults that warrant further research. My approach is patient-specific andmy treatment philosophy requires balance between the physical,biochemical, emotional and electromagnetic systems. I have usedNatcell Thymus and Natcell Liver in the management of liver disease as partof a comprehensive treatment protocol for more than 5 years. My resultshave been consistent and reproducible. The Natcell line of productsare available from Atrium Biotechnologies, Inc. of Quebec City, Canada.

Correspondence:
Dr. Thomas Bayne, D.C.
1535 Lake Cook Rd. Suite 404
Northbrook, Illinois 60062 USA
847-714-1531
Email: tom_bayne@mindspring.com

References

1. Babal, K., Reversing Liver Damage, Nutrition Science News, 2(10), 1997,508-512
2. Cotran, R., Kumar, V., Robbins, S., 4th Edition Robbins PathologicalBasis of Disease, W.B. Saunders Co., 1989.
3. Lesnicar, G., A prospective study of viral hepatitis A and the questionof chronicity. Hepatogastroenterology 35:69, 1988
4. Bernuau, J., et al.: Fulminant and subfulminant liver failure:definitions and causes. Semin. Liver Dis. 6:97, 1986
5. Aggarwal, R., Krawczynski, Hepatitis E: an overview and recent advancesin clinical and laboratory research. J Gastroenterol Hepatol, Jan 2000,15(1): 9-20
6. Berkow, R., Fletcher, A., The Merck Manual of Diagnosis and Therapy; 15thedition. Merck Research Laboratories, Rathway, N.J. 1987, p.905
7. Dworniak, D., et al. Treatment with thymic extract TFX for chronic activehepatitis B. Archivum Immunologiae et Therapiae Experimentalis. 1991,39(5-6): 537
8. Zeman, K., et al. Effect of thymic extract on allogeneic MLR andmitogen-induced responses in patients with chronic active hepatitis B.Immunological Investigations. 1991 Dec, 20(7): 545.
9. Kaido, T., et al. Portal branch ligation with a continuous hepatocytegrowth factor supply makes extensive hepatectomy possible in cirrhotic rats.Hepatology, 1998 Sep; 28(3): 756-60
10. Ohnishi, T., et al. Effect of phosphorylated rat fetuin on the growth ofhepatocytes in primary culture in the presence of human hepatocyte-growthfactor. Evidence that phosphorylated fetuin is a natural modulator ofhepatocyte growth factor. Eur J Biochem 1997 Feb 1; 243(3): 753-61
11. Fujisawa, K., et al, Therapeutic effects of liver hydrosylatepreparation on chronic hepatitis-A double blind, controlled study. Asian MedJ 26,497-526, 1984
12. Freidman, Rockey, Maher. Presentation at the 50th annual meeting of theAmerican Association for the Study of Liver Disease. Oct. 1999.
13. Radchenko, VG et al. The efficacy of immunomodulating preparations intreating patients with chronic cholestatic liver diseases. Vrachebnoe Delo.1992 Nov-Dec, (11-12):38
14. Ueki, T., et al. Hepatocyte growth factor gene therapy of livercirrhosis in rats. Nat Med 1999 Feb; 5(2):226-30
15. Kaido, T., et al. Perioperative continuous hepatocyte growth factorsupply prevents postoperative liver failure in rats with liver cirrhosis. JSurg Res 1998 Feb 1;74(2):173-8